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Interferone als Schlüsselfaktoren für die Pathogenese, Diagnostik und Therapie
Interferons (IFN) belong to a family of related signalling proteins that are classified into the three major types IFN-alpha, IFN-beta (together type...
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Autoinflammatorische Erkrankungen – ein expandierendes Spektrum
Autoinflammatory diseases comprise a growing genetically heterogeneous group of diseases with a broad and variable clinical spectrum. From...
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Autoinflammation – Eine klinische und genetische Herausforderung
In the last two decades clinical rheumatological practice has been confronted with a steadily increasing number of autoinflammatory diseases, the...
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Systemischer Lupus erythematodes – sind Kinder kleine Erwachsene?
Systemic lupus erythematosus (SLE) is a systemic inflammatory disease that can affect any organ of the human body and cause significant damage. As...
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Autoinflammation – Eine klinische und genetische Herausforderung
In the last two decades clinical rheumatological practice has been confronted with a steadily increasing number of autoinflammatory diseases, the...
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GKJR(Gesellschaft für Kinder- und Jugendrheumatologie)-Diagnose- und Therapieoptimierungsboard – neue Wege zu Diagnose und Therapie komplexer Erkrankungen
With the diagnosis and treatment optimization board, the Society for Pediatric and Adolescent Rheumatology (GKJR) has developed a new format for...
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Autoinflammation – Unterschiede bei Kindern und Erwachsenen
Autoinflammatory diseases present as multisystemic inflammation and often manifest in early childhood. In contrast, in a few diseases, e.g., the...
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Grundlagen der Diagnostik primärer Immunstörungen („inborn errors of immunity“)
Inborn errors of immunity (IEI) are a heterogeneous group of nearly 500 diseases characterized by a congenital dysfunction of the immune system. The...
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Immunologisches Basiswissen für die Praxis
The immune system is a human defense system that can be adapted to external conditions and is present ubiquitously throughout the organism. Its main...
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Autoinflammation – Unterschiede bei Kindern und Erwachsenen
Autoinflammatory diseases present as multisystemic inflammation and often manifest in early childhood. In contrast, in a few diseases, e.g., the...
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Was ist gesichert in der Therapie von autoinflammatorischen Fiebererkrankungen?
In the last 20 years the clarification of monogenic periodic febrile diseases has led to the independent concept of autoinflammation. In this...
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Warnzeichen für und moderne Diagnostik von angeborenen Störungen des Immunsystems
BackgroundThe early diagnosis of congenital disorders of the immune system decisively improves the prognosis of patients.
Material and methods ...
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Fortschritte in der Diagnostik und Therapie der juvenilen Dermatomyositis
Juvenile dermatomyositis (JDM) is by far the most frequent inflammatory myopathy in childhood and adolescence. It is clinically characterized by...
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Fieber bei rheumatologischen Erkrankungen
Fever is a frequent and important symptom in patients with rheumatological diseases and can be an expression of activity of the underlying...
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Rolle der Metaflammation als systemische Manifestation bei Stoffwechselerkrankungen
Visceral obesity as a component of the metabolic syndrome is characterized by systemic and local inflammation, which can be quantified in organs...
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Fieber und Entzündung im Kindesalter
Fever and signs of an inflammatory disease are among the most common symptom complexes that lead to an acute pediatric presentation. The generally...
