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Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis
BackgroundMultiple oral insulin-sensitizing agents, such as metformin, thiazolidinediones, inositols, and berberine, have been proven safe and...
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Insulin resistance syndrome presenting with diabetic ketoacidosis — a rare presentation
We report an adolescent male who presented with diabetic ketoacidosis (DKA). He was diagnosed to have type 1 diabetes mellitus at the age of 12 years...
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Insulin-sensitizing agents for infertility treatment in woman with polycystic ovary syndrome: a narrative review of current clinical practice
PurposePolycystic ovary syndrome (PCOS) is an endocrine, metabolic, and reproductive disorder which, according to the Rotterdam criteria, affects up...
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Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients
Background and aimConventional drugs have limitations due to prevalence of contraindications in PCOS patients. To explore the potential effects of...
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Crosstalk between autophagy and insulin resistance: evidence from different tissues
Insulin is a critical hormone that promotes energy storage in various tissues, as well as anabolic functions. Insulin resistance significantly...
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Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome
This study examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α agonist, on the serum biochemical parameters...
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Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic ovulation dysfunction and overabundance of androgens; it...
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Are the antidepressant effects of insulin-sensitizing medications related to improvements in metabolic markers?
Insulin-sensitizing medications were originally used in psychiatric practice to treat weight gain and other metabolic side effects that accompany the...
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Pathophysiological aspects of insulin resistance in Atrial Fibrillation: novel therapeutic approaches
BackgroundInsulin resistance is associated with metabolic disorders including diabetes, obesity, hypertension, and inflammation which are the risk...
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Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients
BackgroundEstimated glucose disposal rate (eGDR), a simple and noninvasive measure of insulin resistance, has been proven to be an independent risk...
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E4orf1-induced reduction in endogenous insulin level is independent of pancreas endocrine function
BackgroundObesity is often associated with hyperinsulinemia due to insulin resistance. In mice models of hyperinsulinemia, adenovirus-derived E4orf1...
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Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway
BackgroundArtichoke ( Cynara scolymus L. ) is a typical element of a traditional Mediterranean diet and has potential health advantages for insulin...
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Unraveling the link between insulin resistance and Non-alcoholic fatty liver disease (or metabolic dysfunction-associated steatotic liver disease): A Narrative Review
ObjectiveNon-alcoholic fatty liver disease (NAFLD) is rapidly becoming a significant global health concern, representing the leading cause of chronic...
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Insulin resistance assessed by estimated glucose disposal rate and risk of incident cardiovascular diseases among individuals without diabetes: findings from a nationwide, population based, prospective cohort study
BackgroundRecent studies have suggested that insulin resistance (IR) contributes to the development of cardiovascular diseases (CVD), and the...
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Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist
BackgroundLiver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent...
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Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies
Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease...
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Brain insulin signalling in metabolic homeostasis and disease
Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ...
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Highlighting the Role of Obesity and Insulin Resistance in Type 1 Diabetes and Its Associated Cardiometabolic Complications
Purpose of ReviewThis narrative review appraises research data on the potentially harmful effect of obesity and insulin resistance (IR) co-existence...
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The effect of mHealth-based exercise on Insulin Sensitivity for patients with Hepatocellular carcinoma and insulin resistance (mISH): protocol of a randomized controlled trial
BackgroundThe importance of insulin resistance is gaining increasing attention as it plays an important role in carcinogenesis in hepatocellular...
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Associations of four surrogate insulin resistance indexes with non-alcoholic steatohepatitis in Chinese patients with obesity: a cross-sectional study
ObjectivesThis study was designed to evaluate the association of four surrogate indexes of IR with NASH in patients with obesity.
Methods ...