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Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion
Combined [ 18 F]FDG PET-cardiac MRI imaging (PET/CMR) is a useful tool to assess myocardial viability and cardiac function in patients with acute...
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Myocardial perfusion assessment in the infarct core and penumbra zones in an in-vivo porcine model of the acute, sub-acute, and chronic infarction
ObjectivesTo assess the longitudinal changes of microvascular function in different myocardial regions after myocardial infarction (MI) using...
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Hydrogels for Cardiac Restorative Support: Relevance of Gelation Mechanisms for Prospective Clinical Use
Purpose of ReviewCardiac tissue regenerative strategies have gained much traction over the years, in particular those utilizing hydrogels. With our...
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Application of Hydrogels in Cardiac Regeneration
Myocardial infarction (MI) is a leading cause of death globally. Due to limited cardiac regeneration, infarcted myocardial tissue is gradually...
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Effect of ticagrelor and prasugrel on remote myocardial inflammation in patients with acute myocardial infarction with ST-elevation: a CMR T1 and T2 map** study
Purpose: Acute myocardial ischaemia triggers a non-specific inflammatory response of remote myocardium through the increase of plasma concentrations...
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Characterizing the immune response to myocardial infarction in pigs
Though myocardial infarction (MI) in pigs is a well-established translational large animal model, it has not yet been widely used for immunotherapy...
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Increased oxygenation is associated with myocardial inflammation and adverse regional remodeling after acute ST-segment elevation myocardial infarction
ObjectivesTo explore the relationships between oxygenation signal intensity (SI) with myocardial inflammation and regional left ventricular (LV)...
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Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for...
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Advancing cardiac regeneration through 3D bioprinting: methods, applications, and future directions
Cardiovascular diseases (CVDs) represent a paramount global mortality concern, and their prevalence is on a relentless ascent. Despite the...
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Second-generation extracellular matrix patch for epicardial infarct repair
Current myocardial infarction treatments focus on improving hemodynamics rather than addressing the problem of lost myocardium impairing left...
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T2 and T2∗ map** in ex situ porcine myocardium: myocardial intravariability, temporal stability and the effects of complete coronary occlusion
Diagnosis of ischaemia-related sudden cardiac death in the absence of microscopic and macroscopic ischaemic lesions remains a challenge for medical...
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Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction
BackgroundWe examined the dynamic response of the myocardium to infarction in a longitudinal porcine study using relaxometry, functional as well as...
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Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?
Purpose of ReviewExciting pre-clinical data presents pluripotent stem cell-derived cardiomyocytes (PSC-CM) as a novel therapeutic prospect following...
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A novel pulsed field ablation system using linear and spiral ablation catheters can create large and durable endocardial and epicardial ventricular lesions in vivo
BackgroundWe investigated the preclinical safety and efficacy of ventricular pulsed field ablation (PFA) using a family of novel, 6-/8-Fr, linear,...
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Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model
BackgroundThe effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There...
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The interplay of galectins-1, -3, and -9 in the immune-inflammatory response underlying cardiovascular and metabolic disease
Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their sugar moieties, forming signaling and adhesion networks...
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Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model
Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment...
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Fully Automatic Scar Segmentation for Late Gadolinium Enhancement MRI Images in Left Ventricle with Myocardial Infarction
Numerous methods have been published to segment the infarct tissue in the left ventricle, most of them either need manual work, post-processing, or...
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Animal models to study cardiac regeneration
Permanent fibrosis and chronic deterioration of heart function in patients after myocardial infarction present a major health-care burden worldwide....
