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A multi-target protective effect of Danggui-Shaoyao-San on the vascular endothelium of atherosclerotic mice
BackgroundAtherosclerosis (AS) is a chronic disease characterized by abnormal blood lipid metabolism, inflammation and vascular endothelial injury....
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Mechanobiology of the endothelium in vascular health and disease: in vitro shear stress models
In recent years, there has been growing evidence that vascular pathologies arise in sites experiencing an altered haemodynamic environment. Fluid...
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Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium
Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current...
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Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium
BackgroundHistone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Histone...
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Seasonal variations in endothelium-dependent flow-mediated vasodilation and endothelium-independent nitroglycerine-induced vasodilation
Cardiovascular mortality has been shown to vary seasonally. However, it has not been determined whether vascular function is affected by the season....
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The endothelium: gatekeeper to lung ischemia-reperfusion injury
The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is...
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VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane
Vascular endothelial cells (VECs) are key players in the formation of neovessels and tumor metastasis, the ultimate cause of the majority of...
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Insights in opiates toxicity: impairment of human vascular mesenchymal stromal cells
The most common pulmonary findings in opiate-related fatalities are congestion and oedema, as well as acute and/or chronic alveolar haemorrhage, the...
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GLP-1RAs and cardiovascular disease: is the endothelium a relevant platform?
Hyperglycemia strongly affects endothelial function and activation, which in turn increases the risk of atherosclerotic cardiovascular disease. Among...
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SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer
BackgroundPulmonary hypertension (PH) complicating idiopathic pulmonary fibrosis (IPF) is associated to worse outcome. There is a great need for a...
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NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels
Impaired endothelium-dependent vasodilation has been suggested to be a key component of coronary microvascular dysfunction (CMD). A better...
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Hypertension and Dyslipidemia: the Two Partners in Endothelium-Related Crime
Purpose of ReviewThe goal of this article is to characterize the endothelium’s role in the development of hypertension and dyslipidemia and to point...
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Absorbed Bioactive Compounds Replicate Guanxin II-Induced Endothelium-Associated in/ex vivo Vasodilation
ObjectiveTo develop an interference-free and rapid method to elucidate Guanxin II (GX II)’s representative vasodilator absorbed bioactive compounds...
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Are Vascular Endothelium and Angiogenesis Effective MicroRNA Biomarkers Associated with the Prediction of Early-Onset Preeclampsia (EOPE) and Adverse Perinatal Outcomes?
MicroRNA is associated with angiogenesis, invasion, proliferation, and vascular endothelial remodeling of various diseases. We aimed to investigate...
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The impact of temperature on vascular function in connection with vascular laser treatment
Pulsed dye lasers are used effectively in the treatment of psoriasis with long remission time and limited side effects. It is, however, not...
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Study of single nucleotide polymorphism of vascular endothelium factor in patients with differentiated thyroid cancer
BackgroundGenetic alterations and high levels of the vascular endothelial growth factor (VEGF) are presumptive risk factors for differentiated...
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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary...
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Extracellular vesicles and their effect on vascular haemodynamics: a systematic review
Extracellular vesicles (EVs) are released from all cell types studied to date and act as intercellular communicators containing proteins, nucleic...
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Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries
Silybin is a flavonolignan extracted from the seeds of Silybum marianum that has been used as a dietary supplement for treating hepatic diseases and...
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Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes
Aims/hypothesisA hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the...
