Search
Search Results
-
Mechanisms and regulation of defensins in host defense
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to...
-
Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis
Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into acute myeloid leukemia. Fatal infection is among the most...
-
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
Clostridium perfringens ( C. perfringens ) infection is recognized as one of the most challenging issues threatening food safety and perplexing...
-
Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections
BackgroundEarly studies indicated that vitamin D (VD) exerted pleiotropic extra-skeletal effects in the airway, but the definite linkage between VD...
-
Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms
PurposeThere is considerable controversy on the role of genetics, mechanical and environmental factors, and, recently, on subclinical infection in...
-
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids
Horseshoe bats host numerous SARS-related coronaviruses without overt disease signs. Bat intestinal organoids, a unique model of bat intestinal...
-
The role of Aβ in Alzheimer’s Disease as an Evolutionary Outcome of Optimized Innate Immune Defense
Alzheimer’s Disease is a progressive manifestation of aging associated with accumulated Amyloid β. It remains frustratingly unclear why this protein...
-
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa ( P. aeruginosa ) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds,...
-
A mammalian lung's immune system minimizes tissue damage by initiating five major sequential phases of defense
The mammalian lungs encounter several pathogens, but have a sophisticated multi-phase immune defense. Furthermore, several immune responses to...
-
Host immune response to infection with porcine circoviruses
Porcine circovirus type 2 (PCV2), which serves as a major causative agent of PCV2-associated diseases and causes severe loss to the pig industry...
-
m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
Neutrophil migration into the site of infection is necessary for antibacterial innate defense, whereas impaired neutrophil migration may result in...
-
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization
Increasing evidence highlights the role of bacteria in the physiopathology of cancer. However, the underlying molecular mechanisms remains poorly...
-
Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions
The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current...
-
-
LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia
Schizophrenia is a complex polygenic disease that is affected by genetic, developmental, and environmental factors. Accumulating evidence indicates...
-
Metataxonomic analysis and host proteome response in dairy cows with high and low somatic cell count: a quarter level investigation
Host response to invasive microbes in the bovine udder has an important role on the animal health and is essential to the dairy industry to ensure...
-
Expression analysis and map** of Viral—Host Protein interactions of Poxviridae suggests a lead candidate molecule targeting Mpox
BackgroundMonkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding...
-
Pathogenesis of Fungal Infections in the Central Nervous System: Host and Pathogen Factors in Neurotropism
Purposeof ReviewFungal CNS infections (CNS-FIs) are associated with significant morbidity and mortality, especially in immunocompromised individuals:...
-
The Mechanism of IL-17 Regulating Neutrophils Participating in Host Immunity of RVVC Mice
Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are the most common lower genital tract infections in reproductive...
