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Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1
Epigenetic factors are well-established players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory...
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Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
Synaptic potentiation underlies various forms of behavior and depends on modulation by multiple activity-dependent transcription factors to...
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YTHDF2 in dentate gyrus is the m6A reader mediating m6A modification in hippocampus-dependent learning and memory
N 6 -methyladenosine (m 6 A) has been demonstrated to regulate learning and memory in mice. To investigate the mechanism by which m 6 A modification exerts...
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Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
Aims/hypothesisChronic hyperglycaemia and recurrent hypoglycaemia are independently associated with accelerated cognitive decline in type 1 diabetes....
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Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
Central nervous system axons have minimal capacity to regenerate in adult brains, hindering memory recovery in Alzheimer’s disease (AD). Although...
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Higher IgG level correlated with vitamin D receptor in the hippocampus of a pristane-induced lupus model
Introduction/objectivesPatients with systemic lupus erythematosus (SLE) may have neurological complications, characterizing neuropsychiatric lupus...
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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
BackgroundEpisodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and...
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Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats
BackgroundLuteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury....
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Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control
Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment...
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Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway
ObjectiveTo investigate whether electroacupuncture (EA) alleviates cognitive impairment by suppressing the toll-like receptor 4 (TLR4)/myeloid...
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Serotonin receptor 4 in the hippocampus modulates mood and anxiety
Serotonin receptor 4 (5-HT 4 R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have...
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Investigation of extracellular matrix genes associated with Alzheimer’s disease in the hippocampus of experimental diabetic model rats
BackroundBoth type 2 diabetes (T2D) and Alzheimer’s disease affect large number of people all over the world, especially in developed countries, and...
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Common network effect-patterns after monoamine reuptake inhibition in dissociated hippocampus cultures
The pharmacological treatment of major depressive disorder with currently available antidepressant drugs is still unsatisfying as response to...
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DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life
Synthetic glucocorticoids (sGC) are administered to women at risk of preterm delivery, approximately 10% of all pregnancies. In animal models,...
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The influence of culture and cognitive reserve on the clinical presentation of behavioural-variant frontotemporal dementia
Characterisation of the clinical profile of behavioural-variant frontotemporal dementia (bvFTD) has predominantly been based on Western samples. Some...
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Dental stem cells improve memory and reduce cell death in rat seizure model
Epilepsy is a common neurological disorder that significantly affects the quality of life of patients. In this study, we aim to evaluate the...
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Adult-born neurons from the dorsal, intermediate, and ventral regions of the longitudinal axis of the hippocampus exhibit differential sensitivity to glucocorticoids
Hippocampal neurogenesis has been shown to play roles in learning, memory, and stress responses. These diverse roles may be related to a functional...
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Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis
Autism spectrum disorder (ASD) is a complicated, neurodevelopmental disorder characterized by social deficits and stereotyped behaviors. Accumulating...
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Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation...
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Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice
Chronic pain is often associated with cognitive decline, which could influence the quality of the patient’s life. Recent studies have suggested that...
