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Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories
Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning...
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From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine **aoyaosan
The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly...
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Neurogenesis-independent mechanisms of MRI-detectable hippocampal volume increase following electroconvulsive stimulation
Electroconvulsive therapy (ECT) is one of the most effective psychiatric treatments but the underlying mechanisms are still unclear. In vivo human...
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Hippocampal hub failure is linked to long-term memory impairment in anti-NMDA-receptor encephalitis: insights from structural connectome graph theoretical network analysis
BackgroundAnti- N -methyl- d -aspartate receptor (NMDAR) encephalitis is characterized by distinct structural and functional brain alterations,...
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Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
Multiscale neuroscience conceptualizes mental illness as arising from aberrant interactions across and within multiple biopsychosocial scales. We...
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Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis
BackgroundResearch work has shown that hippocampal subfields are atrophic to varying extents in multiple sclerosis (MS) patients. However, studies...
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Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial
Hippocampal hyperactivity is a novel pharmacological target in the treatment of schizophrenia. We hypothesized that levetiracetam (LEV), a drug...
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Volumetric hippocampal changes in glioblastoma: a biomarker for neuroplasticity?
PurposeThe pleiotropic effect of gliomas on the development of cognitive disorders and structural brain changes has garnered increasing interest in...
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Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks
Adolescence is a time of rapid neurodevelopment and the endocannabinoid system is particularly prone to change during this time. Cannabis is a...
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Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis
BackgroundAdult hippocampal neurogenesis (AHN) is a clinically significant neural phenomenon. Understanding its molecular regulation would be...
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Hippocampal circuit dysfunction in psychosis
Despite strong evidence of the neurodevelopmental origins of psychosis, current pharmacological treatment is not usually initiated until after a...
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Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer’s Disease
Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental Area (VTA) have been described in Alzheimer’s Disease (AD)....
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Baroreflex sensitivity is associated with markers of hippocampal gliosis and dysmyelination in patients with psychosis
PurposeHippocampal dysfunction plays a key role in the pathology of psychosis. Given hippocampal sensitivity to changes in cerebral perfusion,...
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Prognostic value of scalp EEG ictal patterns in epilepsy surgery of hippocampal sclerosis
BackgroundTemporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) is a surgically treatable epileptic syndrome. While the core of...
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Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
BackgroundAlthough electroconvulsive therapy (ECT) is an effective treatment for depression, ECT cognitive impairment remains a major concern. The...
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Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity
Tachykinin receptor 3 (TACR3) is a member of the tachykinin receptor family and falls within the rhodopsin subfamily. As a G protein-coupled...
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TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner
Aberrant dopaminergic and glutamatergic function, particularly within the striatum and hippocampus, has repeatedly been associated with the...
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High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience
Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired...
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BACE1 in PV interneuron tunes hippocampal CA1 local circuits and resets priming of fear memory extinction
BACE1 is the rate-limiting enzyme for β-amyloid (Aβ) production and therefore is considered a prime drug target for treating Alzheimer’s disease...
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Lithium treatment and human hippocampal neurogenesis
Lithium is a first-line treatment for bipolar disorder, where it acts as a mood-stabilizing agent. Although its precise mechanism remains unclear,...
