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Deciphering tumor immune microenvironment differences between high-grade serous and endometrioid ovarian cancer to investigate their potential in indicating immunotherapy response
BackgroundOvarian cancer is a significant public health concern with a poor prognosis for epithelial ovarian cancer. To explore the potential of...
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Serous Endometrial Intraepithelial Carcinoma with High-Grade Serous Ovarian Carcinoma: A Synchronous Presentation
Synchronous presentation of female genital tract malignancy is common, but not so common with in situ lesions. A female presented with ovarian mass...
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The Clinicopathological and Prognostic Values of Chemotherapy Response Score in Tubo-Ovarian High-Grade Serous Carcinoma
PurposeTubo-ovarian high-grade serous carcinoma is one of the aggressive ovarian tumors. Neoadjuvant chemotherapy has been used in managing the...
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Disparities in treatment modalities and survival among older patients with high-grade serous ovarian cancer
BackgroundUndertreatment of ovarian cancer is common among older women. We aimed to evaluate the treatment modalities offered to older patients and...
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PD-L1 Expression in High-Grade Serous and Clear Cell Ovarian Cancer
PurposeProgrammed death-ligand 1 (PD-L1) was expressed in various gynecology tumors. High-grade ovarian cancers could be a potential target for...
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Prevalence of Germline Pathogenic BRCA mutations in women with High grade Serous ovarian cancers
IntroductionOvarian cancer is the most lethal of all gynaecological malignancies. These malignancies are known to harbour mutations in BRCA genes....
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High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma
BackgroundMechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß...
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NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells
BackgroundGenetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous...
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Complete Response Following Treatment with Olaparib in a Patient with BRCA-Mutant High-Grade Serous Ovarian Cancer and Central Nervous System Metastases
Ovarian cancer is the leading cause of death from gynaecological cancers worldwide. High-grade serous ovarian cancer is the most frequent and...
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Tertiary Lymphoid Structures Are Associated with a Favorable Prognosis in High-Grade Serous Ovarian Cancer Patients
There was accumulating evidence indicating that tertiary lymphoid structures (TLSs) were strongly associated with improved survival and clinical...
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Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer
BackgroundPeritoneal dissemination is the predominant feature of malignant progression in ovarian cancer and is a major cause of poor surgical...
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Differences between complex epithelial neoplasms of the ovary and high-grade serous ovarian cancer: a retrospective observational cohort study
BackgroundComplex epithelial neoplasms of the ovary (CENO), an uncommon pathological histotype in ovarian cancer, comprises adenosquamous carcinoma...
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Neoadjuvant chemotherapy for high-grade serous ovarian cancer: radiologic–pathologic correlation of response assessment and predictors of progression
PurposeNeoadjuvant chemotherapy is often administered for high-grade serous ovarian carcinoma (HGSC) prior to cytoreductive surgery. We evaluated...
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Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer
BackgroundHigh-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and...
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Development and validation of an ultrasound‑based radiomics nomogram to predict lymph node status in patients with high-grade serous ovarian cancer: a retrospective analysis
BackgroundDespite advances in medical imaging technology, the accurate preoperative prediction of lymph node status remains challenging in ovarian...
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Evaluation of the prognostic potential of histopathological subty** in high-grade serous ovarian carcinoma
High-grade serous ovarian carcinoma (HGSOC) can be categorized into four gene expression-based subtypes, with supposedly distinct prognoses and...
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Comparison end-to-end anastomosis with ostomy after secondary surgical cytoreduction for recurrent high-grade serous ovarian cancer: observational single-center study
We conducted an observational single-center cohort study on patients with recurrent high-grade serous ovarian carcinoma that underwent secondary...
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Red Cell Distribution Width and High Grade Serous Ovarian Cancer: Prognostic Marker?
PurposeRed cell distribution width (RDW) has been evaluated as a potential prognostic marker in ovarian cancers, with higher baseline values being...
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The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial)
ObjectiveThis study evaluates the potential superiority of combining paclitaxel-based hyperthermic intraperitoneal chemotherapy (HIPEC) with...
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FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest
Focal adhesion kinase (FAK) is a promising therapeutic target for various cancers and its inhibitor development is in full swing. PF-562271 is a...
