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Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
Lung cancer is a highly prevalent malignancy characterized by significant metabolic alterations. Understanding the metabolic rewiring in lung cancer...
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Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets
PurposeIn type 2 Diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation,...
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Glutamine is a substrate for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway in pancreatic cancer
BackgroundCarbohydrate antigen 19–9 (CA19-9) is the most widely used biomarker for pancreatic cancer. Since CA19-9 closely correlates with patient...
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Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation
Different evidence has indicated metabolic rewiring as a necessity for pancreatic cancer (PC) growth, invasion, and chemotherapy resistance. A...
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The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable disease deaths. Glycolysis is a conserved and...
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O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The...
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Ferulic acid attenuates streptozotocin induced alternation in glycoprotein moiety via regulation of carbohydrate metabolic enzymes in rats
Ferulic acid is a naturally occurring polyphenolic compound that is generally found in plants, vegetables, and fruits. Although ferulic acid has been...
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Evaluation of the wound healing effect of Nishamalaki, an Ayurvedic formulation comprising Curcuma longa and Phyllanthus emblica in aging rats
BackgroundThere are very few drugs available for healing wounds in the aged population, which is more prone to chronic cutaneous wounds that are...
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Mineralocorticoid receptor overactivation in diabetes mellitus: role of O-GlcNAc modification
Hypertension is a significant risk factor for microangiopathy and cardiovascular complications in diabetic patients. The efficacy of...
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Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway
BackgroundDiabetic retinopathy (DR) has become a worldwide concern because of the rising prevalence rate of diabetes mellitus (DM). Despite much...
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Diabetic neuropathy: understanding the nexus of diabetic neuropathy, gut dysbiosis and cognitive impairment
ObjectivesDiabetic neuropathy is a traditional and one of the most prevalent complications of diabetes mellitus. The exact pathophysiology of...
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Glucose and redox metabolism in meiotically blocked in vitro grown mouse antral follicles
PurposeGlucose and redox metabolism characterization in mouse antral follicles with meiotically blocked oocytes, after in vitro follicle culture...
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Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation
Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments....
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Metabolic targeting of malignant tumors: a need for systemic approach
PurposeDysregulated metabolism is now recognized as a fundamental hallmark of carcinogenesis inducing aggressive features and additional hallmarks....
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Evaluating the effectiveness of melatonin in reducing the risk of foot ulcers in diabetic patients
ObjectivesDiabetes and its complications, as a major health concern, are associated with morbidity and mortality around the world. One of these...
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Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication...
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Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a continuous supply of ATP in large quantities, the role of...
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A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin
BackgroundGlucotoxicity in renal tubular epithelial cells (RPTECs) contributes to the pathogenesis of diabetic nephropathy. Sodium-glucose...
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Age-Related Menopause and Carbonyl Stress
AbstractThe review analyzes the published data of some studies on redox homeostasis in women with age-related physiological menopause. Despite the...