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Genomic landscape of colorectal carcinogenesis
PurposeThe molecular pathogenesis of solid tumour was first assessed in colorectal cancer (CRC). To date, ≤ 100 genes with somatic alterations have...
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Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer
Multiple primary malignant neoplasms (MPMN) represent the occurrence of a second malignancy in the same patient within 6 months after the detection...
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Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate cancer
Cancer comes in second place on the list of causes of death worldwide. In 2018, the 5-year prevalence of breast cancer (BC), prostate cancer (PC),...
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Molecular Oncology in Management of Colorectal Cancer
Colorectal cancers are the third most common cancers in the world. Management of both primary and metastatic colorectal cancers has evolved over the...
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Rates and predictors of repeat preoperative endoscopy for elective colorectal resections: how can we avoid repeated procedures?
BackgroundDespite limited endoscopy resources, repeat endoscopy prior to surgery is commonly practised. Our aim was to determine repeat preoperative...
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Imaging approaches for the diagnosis of genetic diseases affecting the female reproductive organs and beyond
This review aims to provide an overview of neoplastic lesions associated with genetic diseases affecting the female reproductive organs. It seeks to...
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Prevalence of colorectal cancer and its precursor lesions in symptomatic patients under 55 years of age undergoing total colonoscopy: results of a large retrospective, multicenter, controlled endoscopy study
PurposeColorectal cancer (CRC) is the second most common cancer in Germany. Around 60,000 people were diagnosed CRC in 2016 in Germany. Since 2019,...
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Second primary malignancies in non-Hodgkin lymphoma: epidemiology and risk factors
With the advancements in therapeutics for non-Hodgkin lymphoma (NHL), the long-term survival of patients with NHL has markedly increased. Second...
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Predictors and rates of prior endoscopic tattoo localization amongst individuals undergoing elective colorectal resections for benign and malignant lesions
BackgroundAppropriate tattooing of suspicious lesions during colonoscopy is critical for surgical planning. However, variability exists in tattoo...
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DNA Mismatch Repair–Deficient Colorectal Carcinoma: Referral Rate for Genetic Cancer Risk Assessment in a Brazilian Cancer Center
BackgroundApproximately 15% of colorectal cancers (CRCs) are deficient in DNA mismatch repair proteins (dMMR), a characteristic that can occur in...
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Gastrointestinal malignancies in pregnancy
Gastrointestinal malignancies, though uncommon in pregnancy, present several unique challenges with regards to diagnosis, staging, and treatment....
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Muir–Torre Syndrome: A Cutaneous Finding Amidst Broader Malignancies
Muir–Torre syndrome (MTS) is a rare autosomal dominant genetic condition resulting from microsatellite instability which is caused by mutations in...
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Effectiveness of a surveillance program of upper endoscopy for upper gastrointestinal cancers in Lynch syndrome patients
Background and aimsLynch syndrome (LS) is the most common cause of hereditary colorectal cancer and is associated with an increased lifetime risk of...
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Recent advances in Lynch syndrome
Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal...
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Metastatic rectal cancer to papillary thyroid carcinoma: a case report and review of literature
BackgroundTumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a...
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Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation
Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2,...
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Cancer Predisposition Genes in Adolescents and Young Adults (AYAs): a Review Paper from the Italian AYA Working Group
Purpose of ReviewThe present narrative systematic review summarizes current knowledge on germline gene mutations predisposing to solid tumors in...
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Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer death. Arising through three...
