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Hereditäre kolorektale Karzinogenese
Hereditary cancer is characterized by the development of certain cancer types in combination with pathogenic germline mutations in genes known to...
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Operative Strategien bei hereditären kolorektalen Karzinomen
Hereditary colorectal cancer (hCRC) represents a major diagnostic and therapeutic challenge. In addition to the usual diagnostic methods, the family...
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Prophylaktische Chirurgie bei hereditären gastrointestinalen Dispositionssyndromen
Hereditary gastrointestinal tumor predisposition syndromes can carry a high risk of cancer and pose a major challenge for patients and treating...
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Das familiäre Pankreaskarzinomsyndrom
In contrast to many other malignant entities the risk factors for pancreatic cancer are mostly unknown. Hereditary factors are causative in about...
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Koloskopiebefunde bei Patienten mit einer Akromegalie
ObjectiveAcromegaly is characterized by chronic hypersecretion of growth hormone (GH) with increased concentration of insulin-like growth factor 1...
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Genetisch stratifizierte Darmkrebstherapie
BackgroundIn hereditary colorectal cancer (CRC), molecular diagnostics have led to precise identification of patients at risk. Positive and negative...
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Acetylsalicylsäure und Prävention kolorektaler Karzinome
Observational and some randomized clinical trials suggest that aspirin protects from occurrence and progression of colorectal neoplasias (adenomas,...
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Acetylsalicylsäure und Prävention kolorektaler Karzinome
Observational and some randomized clinical trials suggest that aspirin protects from occurrence and progression of colorectal neoplasias (adenomas,...
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Prinzipien der humangenetischen Beratung und genetischen Diagnostik in der Gastroenterologie
Genetics is becoming increasingly more important in the field of gastroenterology. Genetic diagnosis differs from conventional clinical medicine in...
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Diagnostik hereditärer Tumorerkrankungen
In 25% of all colon cancers there is a familial aggregation. Hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome is an autosomal...
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Hereditäres nichtpolypöses kolorektales Karzinom
Colorectal cancer (CRC) is the 2nd most common cancer in Germany (incident cases >70,000 persons each year). In 15–25% of all cases, a positive...
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Hereditäres Kolonkarzinom
Colorectal cancer (CRC) is the 2 nd most common cancer in Germany (incidence 70,000 individuals each year). In 20–30% of all cases, a positive...
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Prophylaktische Chirurgie des Pankreas
The goal of prophylactic surgery is to prevent malignant growth in patients with hereditary tumor predisposition. The pancreas presents as...
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