Search
Search Results
-
Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?
BackgroundLipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid...
-
Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression
PurposePolycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, which is closely associated with insulin resistance, glucose and...
-
Effects of riboflavin deficiency and high dietary fat on hepatic lipid accumulation: a synergetic action in the development of non-alcoholic fatty liver disease
BackgroundNon-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Riboflavin, one of water soluble...
-
Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials
BackgroundThe liver was identified as a primary target organ for the chemo-radiological effects of uranyl acetate (UA). Although the anti-oxidant and...
-
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease
Background and purposeAlcoholic liver disease (ALD), a metabolic liver disease caused by excessive alcohol consumption, has attracted increasing...
-
Endocrine, metabolic, and hepatic dysfunction in patients with COVID-19 pneumonia with severe and critically ill status
BackgroundManagement of endocrine and hepatic disorders is very important for better management of patient with COVID-19 infections. Hepatic and...
-
Effects of Hepatic Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide
Background and ObjectiveTirzepatide, a novel, once-weekly, dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
-
PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study
BackgroundThe present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively,...
-
Renal and hepatic dysfunction parameters correlate positively with gender among patients with recurrent malaria cases in Birnin Kebbi, Northwest Nigeria
BackgroundSimultaneous increase in transaminases and bilirubin is an indicator of hepatic dysfunction in malaria. Malaria-induced hyperbilirubinemia...
-
Renal–hepatic–pancreatic dysplasia-1 with a novel NPHP3 genotype: a case report and review of the literature
BackgroundRenal–hepatic–pancreatic dysplasia type 1 (RHPD1) is a rare sporadic and autosomal recessive disorder with unknown incidence. RHPD1 is...
-
Hepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study
BackgroundTissue-specific insulin resistance (IR) predominantly in muscle (muscle IR) or liver (liver IR) has previously been linked to distinct...
-
Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice
Aims/hypothesisHyperglucagonaemia-stimulated hepatic glucose production (HGP) contributes to hyperglycaemia during type 2 diabetes. A better...
-
Potential antioxidant properties and anti-diabetic and hepatic/pancreatic protective effects of dietary Boswellia serrata gum resin powder against oxidative damage in streptozotocin‐induced diabetic rats
The present study was designed to explore the potential antidiabetic and antioxidant capacity and hepatic/pancreatic protective effects of Boswellia...
-
-
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G...
-
Sex-specific alterations in hepatic cholesterol metabolism in low birth weight adult guinea pigs
BackgroundIntrauterine growth restriction and low birth weight (LBW) have been widely reported as an independent risk factor for adult...
-
Alleviating the effect of quinoa and the underlying mechanism on hepatic steatosis in high-fat diet-fed rats
BackgroundNonalcoholic fatty liver disease (NAFLD) is considered the hepatic component of metabolic syndrome and has attracted widespread attention...
-
Pharmacokinetics and safety of niraparib in patients with moderate hepatic impairment
PurposeThe purpose of this study is to characterize niraparib pharmacokinetics (PK) and safety in patients with normal hepatic function (NHF) versus...
-
Challenges in diagnosis and management of acute hepatic porphyrias: from an uncommon pediatric onset to innovative treatments and perspectives
Acute hepatic porphyrias (AHPs) are a family of four rare genetic diseases resulting from a deficiency in one of the enzymes involved in heme...
-
Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease
The liver is often thought of as a single functional unit, but both its structural and functional architecture make it highly multivalent and...
