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Showing 1-20 of 238 results

  1. Comparison of healthspan-related indicators between adults with and without HIV infection aged 18–59 in the United States: a secondary analysis of NAHNES 1999–March 2020

    Background

    As persons with HIV (PWH) live longer they may experience a heightened burden of poor health. However, few studies have characterized the...

    Chen Chen, **ngqi Cao, ... Zunyou Wu in BMC Public Health
    Article Open access 04 May 2023

  2. Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets

    Sirtuins are NAD + -dependent deacetylase and deacylase enzymes that control important cellular processes, including DNA damage repair, cellular...

    Mandy O. J. Grootaert, Martin R. Bennett in Nature Reviews Cardiology
    Article 30 March 2022

  3. Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan

    Recognizing the pivotal role of circadian rhythm in the human aging process and its scalability through wearables, we introduce CosinorAge, a digital...

    **joo Shim, Elgar Fleisch, Filipe Barata in npj Digital Medicine
    Article Open access 04 June 2024

  4. Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants

    Objectives

    To examine the associations between four sleep behaviors and the risk of healthspan termination.

    Methods

    This study included 323,373...

    Muhammed Lamin Sambou, **aoyu Zhao, ... Juncheng Dai in Sleep and Breathing
    Article 06 May 2021

  6. Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan

    Purpose of Review

    Psychological health encompasses a constellation of negative and positive factors—i.e., psychosocial stress, depression, anxiety,...

    Allison E. Gaffey, Erica S. Spatz in Current Atherosclerosis Reports
    Article 19 January 2024

  7. The anti-aging role of metformin, clinical applications to pursue the longevity road

    Background

    Metformin, an oral antidiabetic drug widely used for over 60 years, has been recognized for its safety and effectiveness in the treatment...

    Mirco Pozzi, Pietro Susini, ... Michela Schettino in European Journal of Plastic Surgery
    Article 06 June 2024

  8. The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process

    The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically associated with the regulation of xenobiotic metabolism...

    Sara Abudahab, E. T. Price, ... J. L. McClay in The journal of nutrition, health & aging
    Article 13 April 2023

  9. Hallmarks of cardiovascular ageing

    Normal circulatory function is a key determinant of disease-free life expectancy (healthspan). Indeed, pathologies affecting the cardiovascular...

    Mahmoud Abdellatif, Peter P. Rainer, ... Guido Kroemer in Nature Reviews Cardiology
    Article 16 May 2023

  10. Senotherapy A Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan

    Historically, ageing has been regarded as a biological process that is unalterable. Although it is not possible to halt or reverse this process,...

    Gabriel Bennett in SpringerBriefs in Modern Perspectives on Disability Research
    Book 2024

  11. Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity

    Purpose of Review

    “Healthy aging” is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness....

    Patricia Alejandra Castruita, Stefanie Danielle Piña-Escudero, ... Jennifer S. Yokoyama in Current Genetic Medicine Reports
    Article 26 September 2022

  12. Psychogenic Aging: A Novel Prospect to Integrate Psychobiological Hallmarks of Aging

    Psychological factors are amongst the most robust predictors of healthspan and longevity, yet are rarely incorporated into scientific and medical...

    Manuel Faria, Ariel Ganz, ... Michael Snyder in Translational Psychiatry
    Article Open access 30 May 2024

  13. Dietary regulation in health and disease

    Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated...

    Qi Wu, Zhi-Jie Gao, ... ** Wang in Signal Transduction and Targeted Therapy
    Article Open access 23 July 2022

  14. Shared genomic architectures of COVID-19 and antisocial behavior

    Little is known about the genetics of norm violation and aggression in relation to coronavirus disease 2019 (COVID-19). To investigate this, we used...

    Charleen D. Adams, Jorim J. Tielbeek, Brian B. Boutwell in Translational Psychiatry
    Article Open access 10 May 2022

  15. Growth hormone and aging

    Growth hormone (GH) actions impact growth, metabolism, and body composition and have been associated with aging and longevity. Lack of GH results in...

    Andrzej Bartke in Reviews in Endocrine and Metabolic Disorders
    Article 01 October 2020

  16. Substitution of Sugar-Sweetened Beverages for Other Beverages: Can It Be the Next Step Towards Healthy Aging?

    Purpose of Review

    With the prolongation of life expectancy, the gap between lifespan and “health span,” the disease-free lifespan, has been widening...

    Lale A. Ertuglu, Baris Afsar, ... Mehmet Kanbay in Current Nutrition Reports
    Article 30 September 2021

  17. Minimal-Dose Resistance Training for Improving Muscle Mass, Strength, and Function: A Narrative Review of Current Evidence and Practical Considerations

    Resistance training (RT) is the only non-pharmacological intervention known to consistently improve, and therefore offset age-related declines in,...

    Jackson J. Fyfe, D. Lee Hamilton, Robin M. Daly in Sports Medicine
    Article 25 November 2021

  18. Sirtuins in kidney health and disease

    Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes...

    Luca Perico, Giuseppe Remuzzi, Ariela Benigni in Nature Reviews Nephrology
    Article 06 February 2024

  19. Lifespan extension with preservation of hippocampal function in aged system xc−-deficient male mice

    The cystine/glutamate antiporter system x c − has been identified as the major source of extracellular glutamate in several brain regions as well as a...

    Lise Verbruggen, Gamze Ates, ... Ann Massie in Molecular Psychiatry
    Article Open access 18 February 2022

  20. Exerkines in health, resilience and disease

    The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall...

    Lisa S. Chow, Robert E. Gerszten, ... Michael P. Snyder in Nature Reviews Endocrinology
    Article 18 March 2022
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