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Role of luteinizing hormone urinary levels in the diagnostic and therapeutic management of female central precocious puberty
BackgroundDiagnosing central precocious puberty (CPP) requires an integrated approach based on clinical, biochemical and instrumental data. The...
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Systematic Review: Puberty suppression with GnRH analogues in adolescents with gender incongruity
ContextGender incongruence is defined as disharmony between assigned gender and gender identity. Several interventions are liable in this case...
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Racial Disparities in Medical Management of Uterine Fibroids Prior to Myomectomy or Hysterectomy
The symptomatic burden of uterine fibroids has been demonstrated to disproportionately affect Black and Hispanic women. The primary aim of this study...
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Update on bioethical, medical and fertility issues in gender incongruence during transition age
PurposeMany issues still remain unresolved in the management of pubertal patients with gender incongruence (GI). The aim of this review is to discuss...
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The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome
Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality...
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Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry
BackgroundIn response to the imperative need for standardized support for adolescent Gender Dysphoria (GD), the Italian Academy of Pediatrics, in...
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Extrauterine Endometrial Stromal Sarcoma: A Case Report
Extrauterine endometrial stromal sarcomas are rare malignancies, with 181 cases reported so far. The basic predisposing factor is endometriosis, and...
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Impact of dienogest pretreatment on IVF-ET outcomes in patients with endometriosis: a systematic review and meta-analysis
BackgroundTo comprehensively evaluate the influence of dienogest (DNG) versus non-DNG pretreatment on in vitro fertilization and embryo transfer...
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Modern view on the diagnostics and treatment of adenomyosis
Adenomyosis is identified by the enlargement of the uterus secondary to such areas of the endometrium as the endometrial glands and stroma located...
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Stop GnRH-agonist/GnRH-antagonist protocol: a different insight on ovarian stimulation for IVF
Ovarian stimulation (OS) is one of the key factors in the success of in vitro fertilization-embryo transfer (IVF-ET), by enabling the recruitment of...
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The role of the pediatrician in the management of the child and adolescent with gender dysphoria
Gender dysphoria is a clinical condition characterized by significant distress due to the discordance between biological sex and gender identity....
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Screening for central precocious puberty by single basal Luteinizing Hormone levels
PurposeTo identify cut-off for basal LH levels and for pelvic ultrasound uterine and ovarian parameters indicating an Hypotalamic–Pituitary–Gonadal...
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The effectiveness of relugolix compared with leuprorelin for preoperative therapy before laparoscopic myomectomy in premenopausal women, diagnosed with uterine fibroids: protocol for a randomized controlled study (MyLacR study)
BackgroundThe oral gonadotropin-releasing hormone antagonist relugolix, which temporarily stops menstruation, is used to treat heavy menstrual...
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Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature
BackgroundThe pineal lesion affecting melatonin is a rare cause of central precocious puberty by decreasing the inhibition of...
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Comparison of pregnancy outcomes in women with normal ovarian response to the gonadotropin-releasing hormone agonist protocol using different trigger methods: a single-center retrospective cohort study based on propensity score matching
PurposeTo investigate whether gonadotropin-releasing hormone agonist (GnRH-a) combined with human chorionic gonadotropin (HCG) can improve pregnancy...
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Impact of progestin ovarian stimulation on newborn outcomes: a meta-analysis
ObjectivesTo compare progestin ovarian stimulation protocols with gonadotropin-releasing hormone analogue (agonists and antagonists) protocols on...
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Interventions to prevent or reduce the incidence and severity of ovarian hyperstimulation syndrome: a systematic umbrella review of the best clinical evidence
Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threating iatrogenic complication of the early luteal phase and/or early pregnancy...
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Development of a Novel Patient-Reported Outcome Measure to Assess Symptoms and Impacts of Androgen Deprivation Therapy for Advanced Prostate Cancer
IntroductionThis qualitative research study was conducted to develop a novel, comprehensive, patient-reported outcome measure (PRO), the “Symptoms...
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The dilemma of the trigger timing in IVF: a review
BackgroundTriggering final oocyte maturation is a pivotal step in modern patient-tailored IVF/ICSI treatment, securing the optimal number of mature...