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Reversal of NAFLD After VSG Is Independent of Weight-Loss but RYGB Offers More Efficacy When Maintained on a High-Fat Diet
PurposeBariatric surgery is emerging as an effective treatment for obesity and the metabolic syndrome. Recently, we demonstrated that Roux-en-Y...
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Hepatic glucose metabolism in the steatotic liver
The liver is central in regulating glucose homeostasis, being the major contributor to endogenous glucose production and the greatest reserve of...
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The two-cell model of glucose metabolism: a hypothesis of schizophrenia
Schizophrenia is a chronic and severe mental disorder that affects over 20 million people worldwide. Common symptoms include distortions in thinking,...
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The biallelic novel pathogenic variants in AGL gene in a chinese patient with glycogen storage disease type III
BackgroundGlycogen storage disease type III (GSD III) is a rare autosomal recessive glycogenolysis disorder due to AGL gene variants, characterized...
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Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model
BackgroundThe medicinal plant Citrullus colocynthis (L.) Schrad. ( C. colocynthis ) may benefit patients at different phases of diabetes by attuning...
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Glycogen storage diseases
Glycogen storage diseases (GSDs) are a group of rare, monogenic disorders that share a defect in the synthesis or breakdown of glycogen. This Primer...
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Secondary diabetes mellitus in pheochromocytomas and paragangliomas
Secondary diabetes mellitus (DM) in secretory pheochromocytomas and paragangliomas (PPGLs) is encountered in up to 50% of cases, with its...
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100 years of glucagon and 100 more
The peptide hormone glucagon, discovered in late 1922, is secreted from pancreatic alpha cells and is an essential regulator of metabolic...
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Severe perioperative lactic acidosis in a pediatric patient with glycogen storage disease type Ia: a case report
BackgroundGlycogen storage disease (GSD) is a group of rare inherited metabolic disorders caused by enzyme deficiencies in glycogen catabolism. GSD...
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Unravelling the effect of renal denervation on glucose homeostasis: more questions than answers?
Renal Denervation (RDN) is an interventional, endovascular procedure used for the management of hypertension. The procedure itself aims to ablate the...
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Glucose Metabolism and Stress Hyperglycemia in Critically Ill Children
Abnormalities in glucose metabolism and stress hyperglycemia (SH) are commonly seen in critically ill children. While SH may represent an adaptive...
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Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
Aims/hypothesisAs a result of early loss of the glucagon response, adrenaline is the primary counter-regulatory hormone in type 1 diabetes....
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The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule
Lactate has previously been considered a metabolic waste and is mainly involved in exercise-induced fatigue. However, recent studies have found that...
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Disruptive role of trona on hepatic glucose metabolism in rats
PurposeTrona is a hydrated sodium salt commonly used as food additives for tenderizing tough foods in develo** countries. Its long-term consumption...
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Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus
Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound...
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Multi-organ denervation: a novel approach to combat cardiometabolic disease
Cardiometabolic disorders are associated with a substantial loss in quality of life and pose a large burden on healthcare systems worldwide....
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Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases
Insulin and glucagon exert opposing effects on glucose metabolism and, consequently, pancreatic islet β-cells and α-cells are considered functional...
