Search
Search Results
-
Tall stature and gigantism in transition age: clinical and genetic aspects—a literature review and recommendations
PurposeTall stature is defined as height greater than the threshold of more than 2 standard deviations above the average population height for age,...
-
Neuropathic foot ulcers in the tallest patients with acromegalic gigantism: a common and significant problem. Historical overview
PurposeWe present a historical overview on neuropathic ulcers in patients with acromegalic gigantism.
Materials and methodsThe case histories of 6...
-
Germline AIP variants in sporadic young acromegaly and pituitary gigantism: clinical and genetic insights from a Han Chinese cohort
PurposeVariants in the Aryl hydrocarbon receptor-interacting protein ( AIP ) gene have been identified in sporadic acromegaly and pituitary gigantism,...
-
Gigantism: microsurgical treatment by transsphenoidal approach and prognostic factors
PurposeWe present the results of transsphenoidal microsurgical treatment in 14 patients with gigantism. The influence on the prognosis of factors...
-
Type II Pfieffer misdiagnosed as Crouzon syndrome with additional features of supernumerary teeth and localized symmetrical gigantism: a case report
BackgroundPfieffer syndrome is among the syndromes seen in the recognized variant of the FGFR2 gene. There are several conditions related to this...
-
Huge typical pulmonary carcinoid presented with gigantism syndrome
A 27-year-old male patient presented with cough and right-sided, light thoracic pain. His physical appearance showed typical features of gigantism....
-
Genetics, clinical features and outcomes of non-syndromic pituitary gigantism: experience of a single center from Sao Paulo, Brazil
PurposeNon-syndromic pituitary gigantism (PG) is a very rare disease. Aryl hydrocarbon receptor-interacting protein ( AIP ) and G protein-coupled...
-
Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases
Pituitary adenomas are rare in children and young people under the age of 19 (hereafter referred to as CYP) but they pose some different diagnostic...
-
Pituitary macroadenomas in childhood and adolescence: a clinical analysis of 7 patients
BackgroundPituitary adenomas (PPAs) are uncommon in childhood and adolescence, accounting for 2–6% of all intracranial neoplasms. Delayed puberty,...
-
Hormonal Diseases A Guide for the Layperson
Written by a recognized expert in the field, this accessible book acquaints the lay reader with the main features of hormonal diseases, their...
-
Familial glucocorticoid deficiency presenting with hyperpigmentation, gigantism, and motor development delay: a case report
BackgroundFamilial glucocorticoid deficiency is a rare autosomal recessive disorder characterized by isolated glucocorticoid deficiency. Most...
-
Dante Alighieri (1265–1321): an “infernal” endocrinological observation
The year 2021 marks the 700th anniversary of Dante’s death. Is it appropriate to celebrate this anniversary in a journal of endocrinology? The answer...
-
RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone AIP , result in young-onset growth hormone secreting...
-
The causes and consequences of pituitary gigantism
In the general population, height is determined by a complex interplay between genetic and environmental factors. Pituitary gigantism is a rare but...
-
Clinical presentation and recurrence of pituitary neuroendocrine tumors: results from a single referral center in Colombia
IntroductionPituitary neuroendocrine tumors (PitNETs) represent 15–18.2% of all intracranial tumors. Their clinical presentation can range from...
-
Domestication of aromatic medicinal plants in Mexico: Agastache (Lamiaceae)—an ethnobotanical, morpho-physiological, and phytochemical analysis
BackgroundMost reports of domesticated plants that involve a domestication gradient or inter-specific hybridization in Mexico have focused on those...
-
An update on, and genetics of refractory adenomas of childhood
Pituitary adenomas in childhood tend to be more frequently due to germline genetic changes and are often diagnosed at late stages due to delayed...
-
Beckwith–Wiedemann syndrome with juvenile fibrous nodules and lobular breast tumors: a case report and review of the literature
BackgroundBeckwith–Wiedemann syndrome (BWS) is a genomic imprinting disorder caused by diverse genetic and/or epigenetic disorders of chromosome...
-
Congenital hypopituitarism in two brothers with a duplication of the ‘acrogigantism gene’ GPR101: clinical findings and review of the literature
PurposeCongenital hypopituitarism (CH) can cause significant morbidity or even mortality. In the majority of patients, the etiology of CH is unknown....
