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Expert Consensus on Geographic Atrophy in the EU: A Call for Urgent Policy Action
Geographic atrophy is an eye disease that greatly interferes with the daily lives of patients and their families, posing a serious threat to the...
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Treating patients with geographic atrophy: are we there yet?
Geographic atrophy (GA) is a progressive degenerative disease that significantly contributes to visual impairment in individuals aged 50 years and...
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Advancements in Imaging and Therapeutic Options for Dry Age-Related Macular Degeneration and Geographic Atrophy
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, with dry AMD (d-AMD) leading to geographic atrophy (GA) and...
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Future perspectives for treating patients with geographic atrophy
PurposeGeographic atrophy (GA) is a late-stage form of age-related macular degeneration (AMD) characterized by the expansion of atrophic lesions in...
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OCT risk factors for 2-year foveal involvement in non-treated eyes with extrafoveal geographic atrophy and AMD
PurposeTo assess the relationship of optical coherence tomography (OCT) findings and progression to foveal atrophy in a cohort of eyes with...
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Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study
BackgroundTo describe the occurrence, rate of geographic atrophy (GA) expansion, and changes in visual acuity (VA) after reabsorption of subfoveal...
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Structural OCT and OCT angiography biomarkers associated with the development and progression of geographic atrophy in AMD
BackgroundGeographic atrophy (GA) is an advanced, irreversible, and progressive form of age-related macular degeneration (AMD). Structural optical...
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Impact of slab selection on the relationship between choriocapillaris flow deficits and enlargement rate of geographic atrophy
ObjectiveTo evaluate the effect of changing slab position on the correlation between choriocapillaris (CC) flow deficits (FD) in eyes with geographic...
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Two potentially distinct pathways to geographic atrophy in age-related macular degeneration characterized by quantitative fundus autofluorescence
Background/AimsTo demonstrate two distinct pathways to geographic atrophy (GA) that originate from soft drusen/ pigment epithelial detachments (PEDs)...
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Perspectives from clinical trials: is geographic atrophy one disease?
Geographic atrophy (GA) is currently an untreatable condition. Emerging evidence from recent clinical trials show that anti-complement therapy may be...
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Sequential structural and functional change in geographic atrophy on multimodal imaging in non-exudative age-related macular degeneration
PurposeTo investigate the temporal order of photoreceptor atrophy, retinal pigment epithelium (RPE) atrophy and visual acuity loss in patients with...
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Evaluating the Effects of C3 Inhibition on Geographic Atrophy Progression from Deep-Learning OCT Quantification: A Split-Person Study
IntroductionTo evaluate the effect pegcetacoplan, a C3 and C3b inhibitor, on the rate of progression of geographic atrophy (GA) as assessed by...
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Exploring patient acceptability of emerging intravitreal therapies for geographic atrophy: A mixed-methods study
Background/ObjectivesThe acceptability of emerging intravitreal therapies for patients with Geographic Atrophy (GA) is currently unknown. This study...
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Vision-related quality of life is selectively affected by comorbidities in patients with geographic atrophy
BackgroundThe atrophic late stage of age-related macular degeneration (AMD) is termed geographic atrophy (GA), and affects visual acuity (VA) as well...
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Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial
Background/ObjectivesTo assess the safety and efficacy of avacincaptad pegol (ACP), a C5 inhibitor, for geographic atrophy (GA) secondary to...
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The influence of the topographic location of geographic atrophy on vision-related quality of life in nonexudative age-related macular degeneration
PurposeTo examine associations between the topographic distribution of geographic atrophy (GA) and vision-related quality of life (VRQoL).
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Complement cascade inhibition in geographic atrophy: a review
The pathophysiology of dry age-related macular degeneration (AMD) and specifically geographic atrophy (GA) has been linked to the complement cascade....
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Content Validity and Cognitive Debriefing of a Patient-Reported Outcome Instrument Evaluating Symptoms and Disease Impact in Patients with Geographic Atrophy
IntroductionGeographic atrophy (GA) occurs in the later stages of dry age-related macular degeneration (AMD) and impairs visual acuity, eventually...
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C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the...
