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Risk of Liver Cancer in MASLD: Role of Genetic Risk Scores
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the fastest growing cause of hepatocellular carcinoma (HCC). Several risk factors...
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The Relationship Between Genetic Risk for Insomnia and Psychiatric Disorders
Purpose of ReviewInsomnia has a bi-directional relationship with both psychiatric and addictive disorders, and recent twin studies have shown an...
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Genetic Contributions to Risk of Adverse Pregnancy Outcomes
Purpose of ReviewAdverse pregnancy outcomes (APOs), including hypertensive disorders of pregnancy (HDP), low birthweight (LBW), and preterm birth...
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Non-Genetic Risk Factors of Alzheimer’s Disease: An Updated Umbrella Review
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by intricate genetic and environmental etiology. The...
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The Apo gene's genetic variants: hidden role in Asian vascular risk
Vascular risk factors, including diabetes, hypertension, hyperlipidemia, and obesity, pose significant health threats with implications extending to...
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Nightmares share genetic risk factors with sleep and psychiatric traits
Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are...
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Utility of genetic risk scores in type 1 diabetes
Iterative advances in understanding of the genetics of type 1 diabetes have identified >70 genetic regions associated with risk of the disease,...
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Advancing the communication of genetic risk for cardiometabolic diseases: a critical interpretive synthesis
BackgroundGenetics play an important role in risk for cardiometabolic diseases—including type 2 diabetes, cardiovascular disease and obesity....
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Ambient air pollution, genetic risk and telomere length in UK biobank
BackgroundTelomere length (TL) is a biomarker of genomic aging. The evidence on the association between TL and air pollution was inconsistent....
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Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions
Children with rare neurodevelopmental genetic conditions (ND-GCs) are at high risk for a range of neuropsychiatric conditions. Sleep symptomatology...
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Neuroanatomical correlates of genetic risk for obesity in children
Obesity has a strong genetic component, with up to 20% of variance in body mass index (BMI) being accounted for by common polygenic variation. Most...
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Sleep patterns, genetic susceptibility, and risk of cirrhosis among individuals with nonalcoholic fatty liver disease
BackgroundThe associations between sleep patterns or behaviors and the risk of cirrhosis and the influence of genetic susceptibility on these...
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Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification
BackgroundFamily history, and genetic and non-genetic risk factors can stratify women according to their individual risk of develo** breast cancer....
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Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk
Genome-wide association studies (GWAS) identify genetic variants associated with a trait, regardless of how those variants are associated with the...
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Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study
Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform...
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Genetic Testing for Cancer Risk and Perceived Importance of Genetic Information Among US Population by Race and Ethnicity: a Cross-sectional Study
BackgroundGenetic testing can help determine the risk of many cancers and guide cancer prevention and treatment plans. Despite increasing concern...
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Comparative analysis of genetic risk scores for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy
BackgroundIn recent years, Genome-Wide Association Studies (GWAS) has identified risk variants related to complex diseases, but most genetic variants...
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A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis
BackgroundGenetic and epigenetic factors are associated with the development of alcohol-associated liver disease (AALD). The single nucleotide...
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Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19
BackgroundCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was varied in disease...
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Particulate matter 2.5 causally increased genetic risk of autism spectrum disorder
BackgroundGrowing evidence suggested that particulate matter (PM) exhibit an increased risk of autism spectrum disorder (ASD). However, the causal...
