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The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable socioeconomic implications worldwide. Twin and family-based...
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Rare genetic brain disorders with overlap** neurological and psychiatric phenotypes
Understanding rare genetic brain disorders with overlap** neurological and psychiatric phenotypes is of increasing importance given the potential...
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The Relationship Between Genetic Risk for Insomnia and Psychiatric Disorders
Purpose of ReviewInsomnia has a bi-directional relationship with both psychiatric and addictive disorders, and recent twin studies have shown an...
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An algorithm to identify patients aged 0–3 with rare genetic disorders
BackgroundWith over 7000 Mendelian disorders, identifying children with a specific rare genetic disorder diagnosis through structured electronic...
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Genotypic and phenotypic heterogeneity among Chinese pediatric genetic white matter disorders
BackgroundThe pediatric genetic white matter disorders are characterized by a broad disease spectrum. Genetic testing is valuable in the diagnosis....
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Genetic etiology of progressive pediatric neurological disorders
BackgroundThe aim of the study was to characterize molecular diagnoses in patients with childhood-onset progressive neurological disorders of...
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Genetic Disorders in Pediatric Rheumatology Clinic: When to Suspect, and Why?
Just under a decade ago, most children with genetic disorders received a phenotypic diagnosis, often by atlas matching. With advances in genomics...
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Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment
There is widespread overlap across major psychiatric disorders, and this is the case at different levels of observations, from genetic variants to...
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Genetic pain loss disorders
Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory neuropathies and, if autonomic nerves are involved, hereditary...
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Unraveling the genetic collagen connection: clinical and therapeutic insights on genetic connective tissue disorders
Hereditary connective tissue disorders include more than 200 conditions affecting different organs and tissues, compromising the biological role of...
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Redefining cerebral palsies as a diverse group of neurodevelopmental disorders with genetic aetiology
Cerebral palsy is a clinical descriptor covering a diverse group of permanent, non-degenerative disorders of motor function. Around one-third of...
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Genetic network structure of 13 psychiatric disorders in the general population
Psychiatric disorders frequently co-occur and share common symptoms and genetic backgrounds. Previous research has used genome-wide association...
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Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?
The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this...
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Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology
Improved understanding of the shared genetic architecture between psychiatric disorders and brain white matter may provide mechanistic insights for...
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Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Current literature suggests that people with psychiatric disorders have a higher risk of COVID-19 infection and a worse prognosis of the disease. We...
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Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts
The role of genetic testing in neurologic clinical practice has increased dramatically in recent years, driven by research on genetic causes of...
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The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders
The fornix is a white matter bundle located in the center of the hippocampaldiencephalic limbic circuit that controls memory and executive functions,...
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Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets
Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) show a substantial...
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Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) encompass a spectrum of genetic diseases with a common pathogenesis of defects in telomerase...
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Genetic architecture of brain age and its causal relations with brain and mental disorders
The difference between chronological age and the apparent age of the brain estimated from brain imaging data—the brain age gap (BAG)—is widely...
