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Connecting G protein-coupled estrogen receptor biomolecular mechanisms with the pathophysiology of preeclampsia: a review
BackgroundThroughout the course of pregnancy, small maternal spiral arteries that are in contact with fetal tissue undergo structural remodeling,...
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Improvement of Cardiovascular Function in Aging Females by the Prolonged Activation of G Protein-Coupled Estrogen Receptor
AbstractAmple evidence suggests that estrogen replacement therapy is associated with beneficial effects with regard to cardiovascular diseases when...
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Evaluation of serum G protein-coupled estrogen receptor 1 (GPER-1) levels in patients with androgenetic alopecia
The effect of oestrogens in androgenetic alopecia (AGA) pathophysiology has not been clearly understood. However, they are considered to have a place...
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Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including...
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Nuclear receptor co-repressor NCOR2 and its relation to GPER with prognostic impact in ovarian cancer
PurposeThe significance of the non-classical G-protein-coupled estrogen receptor (GPER) as positive or negative prognostic factor for ovarian cancer...
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Estrogen and Androgen Receptor Status in Uterosacral Ligaments of Women with Pelvic Organ Prolapse Stratified by the Pelvic Organ Prolapse Histology Quantification System
Menopause is a significant risk factor for pelvic organ prolapse (POP), suggesting that ovarian sex steroids play a major role in the etiology of the...
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G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival
PurposeThe present study intended to further elucidate the role of G protein-coupled estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the...
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Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of death globally for men and women. Premenopausal women have a lower incidence of hypertension and...
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Targeting estrogen receptor signaling for treating heart failure
Heart failure (HF) is a significant public health problem worldwide. It has long been noted that premenopausal women, compared to postmenopausal...
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XAF1 destabilizes estrogen receptor α through the assembly of a BRCA1-mediated destruction complex and promotes estrogen-induced apoptosis
X-linked inhibitor of apoptosis-associated factor 1 (XAF1) is a pro-apoptotic tumor suppressor that is frequently inactivated in multiple human...
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Estrogen Receptor and the Unfolded Protein Response: Double-Edged Swords in Therapy for Estrogen Receptor-Positive Breast Cancer
Estrogen receptor α (ERα) is a target for the treatment of ER-positive breast cancer patients. Paradoxically, it is also the initial site for...
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Unraveling Estrogen and PCSK9’s Roles in Lipid Metabolism Disorders among Ovariectomized Mice
We explore the interaction between estrogen and PCSK9 and their collective impact on lipid metabolism, especially concerning the regulation of...
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Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
BackgroundMigraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid...
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Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background
PurposeA large number of studies have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent controversy exists....
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Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α
In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into...
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Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function
Human menopause is widely associated with impaired skeletal muscle quality and significant metabolic dysfunction. These observations pose significant...
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Menstrual migraine is caused by estrogen withdrawal: revisiting the evidence
ObjectiveTo explore and critically appraise the evidence supporting the role of estrogen withdrawal in menstrual migraine.
Main bodyMenstrual...
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G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen
BackgroundThe role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly...
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Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary
New insights have been thrown for understanding the significant role of estrogen on various systems of humans. Increasing evidences have determined...
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Cancer-biomarkers associated with sex hormone receptors and recent therapeutic advancements: a comprehensive review
Hormones and its regulation plays vital role in causing breast, prostate, ovarian and endometrial cancers collectively known as hormone-sensitive...
