Search
Search Results
-
Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
PurposeWe hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more...
-
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form...
-
Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies
The retina is a potential source of biomarkers for the detection of neurodegenerative diseases. Accumulation of phosphorylated tau (p-tau) in the...
-
Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein
PurposeThere is an unmet need for compounds to detect fibrillar forms of alpha-synuclein (αSyn) and 4-repeat tau, which are critical in many...
-
Tau depletion in human neurons mitigates Aβ-driven toxicity
Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological...
-
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as...
-
Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer’s disease (AD), and biomarkers...
-
Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of...
-
Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant...
-
Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or...
-
Friend or foe: role of pathological tau in neuronal death
Neuronal death is one of the most common pathological hallmarks of diverse neurological diseases, which manifest varying degrees of cognitive or...
-
Tau reduction attenuates autism-like features in Fmr1 knockout mice
BackgroundFragile X syndrome (FXS) is a leading cause of autism spectrum disorder (ASD) and resulted from a loss of the FMR1 -encoded fragile X...
-
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple...
-
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in...
-
Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus
Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of paired helical filaments is a major hallmark of...
-
Mitotic phosphorylation of Tau/MAPT modulates cell cycle progression in prostate cancer cells
PurposeTau/MAPT (microtubule associated protein tau) protein is actively studied for the pathologic consequences of its aberrant proteostasis in...
-
Interplay of tau and functional network connectivity in progressive supranuclear palsy: a [18F]PI-2620 PET/MRI study
PurposeProgressive supranuclear palsy (PSP) is primary 4-repeat tauopathy. Evidence spanning from imaging studies indicate aberrant connectivity in...
-
Predictive Utility of Plasma Amyloid and Tau for Cognitive Decline in Cognitively Normal Adults
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disease affecting mostly elderly adults. Recent diagnostic criteria for AD...
-
p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to...
-
Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis
ObjectivesTo evaluate the difference of tau burden between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs) or other...
