Search
Search Results
-
Exposure–Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome
IntroductionTrofinetide was recently approved for the treatment of Rett syndrome (RTT) on the basis of the efficacy and safety findings of the...
-
Modeling clothing as a secondary source of exposure to SVOCs across indoor microenvironments
BackgroundEvidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and...
-
Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants
BackgroundAtopic dermatitis (AD) is a chronic, inflammatory disease characterized by dry, pruritic skin. In the U.S., the prevalence of AD has...
-
An Exploratory Study on Strategies Adopted by Parents Who Use E-Cigarettes to Negotiate Risk Perceptions of Their Children’s Secondhand Exposure and Parental Role Modeling
Existing health messages mainly targeted youth susceptible to va** or parents who do not have much knowledge about e-cigarettes. This study makes a...
-
Longitudinal Exposure—Response Modeling of Multiple Indicators of Alzheimer’s Disease Progression
BackgroundProgression in Alzheimer’s disease manifests as changes in multiple biomarker, cognitive, and functional endpoints. Disease progression...
-
Computational modeling method to estimate secondhand exposure potential from exhalations during e-vapor product use under various real-world scenarios
Potential secondhand exposure of exhaled constituents from e-vapor product (EVP) use is a public health concern. We present a computational modeling...
-
A modular mechanistic framework for estimating exposure to SVOCs: Next steps for modeling emission and partitioning of plasticizers and PFAS
AbstractEstimates of human exposure to semi-volatile organic compounds (SVOCs) such as phthalates, phthalate alternatives, and some per- and...
-
Depression mediates the relationship between exposure to stigma and medication adherence among people living with HIV in low-resource setting: a structural equation modeling approach
This study hypothesizes that depression mediates the association between exposure to stigma and medication non-adherence in people living with HIV...
-
Modeling the structural relationships between trauma exposure with substance use tendency, depression symptoms, and suicidal thoughts in individuals with earthquake trauma experience: the mediatory role of peritraumatic dissociation and experiential avoidance
BackgroundDespite the fact that studies indicate that earthquake trauma is associated with numerous psychological consequences, the mediating...
-
Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments
Background and ObjectiveDoravirine is currently not recommended for pregnant women living with human immunodeficiency virus because efficacy and...
-
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
Background and ObjectiveThe use of bedaquiline as a treatment option for drug-resistant tuberculosis meningitis (TBM) is of interest to address the...
-
Impact of ambient air pollution exposure during pregnancy on adverse birth outcomes: generalized structural equation modeling approach
BackgroundAir pollution and several prenatal factors, such as socio-demographic, behavioural, physical activity and clinical factors influence...
-
Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
IntroductionSPI-62 is a small-molecule 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor exhibiting complicated nonlinear pharmacokinetics...
-
Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
Background and ObjectiveDaptomycin has been recommended in the treatment of bone and joint infection. Previous work showed that the approved dosage...
-
Local exposure misclassification in national models: relationships with urban infrastructure and demographics
BackgroundNational-scale linear regression-based modeling may mischaracterize localized patterns, including hyperlocal peaks and neighborhood- to...
-
Post-natal steroid exposure in very low birthweight neonates and associations with acute kidney injury
ObjectiveThe relationship between adrenal insufficiency (AI), post-natal steroids (PNS) and neonatal acute kidney injury (AKI) remains understudied....
-
Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study
BackgroundMen who have sex with men (MSM) in Brazil remain disproportionately affected by HIV. We estimated the potential incidence reduction by five...
-
PACEMweb: a tool for aggregate consumer exposure assessment
BackgroundTo ascertain the safe use of chemicals that are used in multiple consumer products, the aggregate human exposure, arising from combined use...
-
A Review of Causal Inference Methods for Estimating the Effects of Exposure Change when Incident Exposure Is Unobservable
Purpose of ReviewResearch questions on exposure change and health outcomes are both relevant to clinical and policy decision making for public...
-
Collaborative Modeling of the Tick-Borne Disease Social-Ecological System: A Conceptual Framework
Hard-bodied ticks have become a major concern in temperate regions because they transmit a variety of pathogens of medical significance. Ticks and...
