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Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway
BackgroundAcute pancreatitis (AP) is one of the most common acute abdominal disorders; due to the lack of specific treatment, the treatment of acute...
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Plasma Exosomes Aggravate Acute Pancreatitis by Promoting M1 Polarization of Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis
Background and AimsObesity may be a risk factor for severe acute pancreatitis (SAP). However, its precise mechanism is not yet fully understood.
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Characterization of Duodenal Microbiota in Patients with Acute Pancreatitis and Healthy Controls
ObjectiveThe small intestinal bacterial overgrowth (SIBO) in acute pancreatitis correlates with the severity of the disease. However, corresponding...
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Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis
Pancreatitis is an inflammatory disease, which is triggered by adverse events in acinar cells of the pancreas. After the initial injury, infiltration...
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Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways
Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known...
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Acute Pancreatitis: Diagnosis and Treatment
Acute pancreatitis is a common indication for hospital admission, increasing in incidence, including in children, pregnancy and the elderly....
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Automated machine learning for early prediction of acute kidney injury in acute pancreatitis
BackgroundAcute kidney injury (AKI) represents a frequent and grave complication associated with acute pancreatitis (AP), substantially elevating...
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Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis
BackgroundThe incidence of hypertriglyceridemic acute pancreatitis (HTG-AP) is increasing. Although the guideline defines the diagnostic criteria as...
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Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period
BackgroundThe worldwide incidence of acute pancreatitis (AP) is increasing, but the dominant etiology of AP may vary by country. Mixed etiologies are...
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Vitamin B6 ameliorates acute pancreatitis by suppressing the caspase3 signaling pathway
BackgroundAcute pancreatitis (AP) is a prevalent exocrine inflammatory disorder of the pancreas characterized by pancreatic inflammation and injury...
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Effects of probiotics on pancreatic inflammation and intestinal integrity in mice with acute pancreatitis
BackgroundSevere acute pancreatitis is a potentially life-threatening disease. Despite being a common disorder, acute pancreatitis lacks a specific...
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Effectiveness of neuromuscular electrical stimulation in severe acute pancreatitis complicated patients with acute respiratory distress syndrome: study protocol for a randomized controlled trial
BackgroundSevere acute pancreatitis complicated by acute respiratory distress is a common cause of intensive care unit (ICU) admission. These...
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Acute pancreatitis and metabolic syndrome: genetic correlations and causal associations
BackgroundAlthough there is a definite correlation between the Metabolic Syndrome (MetS) and Acute Pancreatitis (AP), cause is yet unknown. The...
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Identification of early predictors for infected necrosis in acute pancreatitis
BackgroundIn acute pancreatitis, secondary infection of pancreatic necrosis is a complication that mostly necessitates interventional therapy. A...
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Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation
ObjectiveTo identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge., (Dahuang-Danshen, DH-DS) and the mechanism underlying its...
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Clinical Significance of Serum Nitric Oxide, Urine Nitric Oxide, and Urinary Nitric Oxide-to-Creatinine Ratio in Acute Pancreatitis
To estimate the serum nitric oxide (NO), urine nitric oxide level, and urinary nitric oxide-to-creatinine ratio in patients with acute pancreatitis...
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Elevated IRF9 raised cell apoptosis and tissue damages through suppressing SIRT1 in hyperlipidemia acute pancreatitis with liver injury
BackgroundHyperlipidemia is a vital etiology of acute pancreatitis (AP), 12 to 20% of which have a history of hyperlipidemia. Multiple organ failure...
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Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier
BackgroundAcute pancreatitis (AP) is a recurrent inflammatory disease. Studies have shown that intestinal homeostasis is essential for the treatment...
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Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice
AimAcute pancreatitis is a common and potentially serious condition. However, a specific treatment for this condition is still lacking. Genistein,...
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Early assessment of acute kidney injury in severe acute pancreatitis with multimodal DWI: an animal model
ObjectivesTo evaluate the feasibility of multimodal diffusion-weighted imaging (DWI) for detecting the occurrence and severity of acute kidney injury...
