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Development of LC-HRMS untargeted analysis methods for nasal epithelial lining fluid exposomics
BackgroundThe nasal mucosa, as a primary site of entry for inhaled substances, contains both inhaled xenobiotic and endogenous biomarkers. Nasal...
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Exhaled breath particles as a novel tool to study lipid composition of epithelial lining fluid from the distal lung
BackgroundSurfactant phospholipid (PL) composition plays an important role in lung diseases. We compared the PL composition of non-invasively...
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Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p
BackgroundCircular RNA (circRNA) has the potential to serve as a crucial regulator in the progression of bronchial asthma. The objective of this...
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TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells
Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive...
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Amniotic fluid stem cell administration can prevent epithelial injury from necrotizing enterocolitis
BackgroundStem cell therapy has been proven to rescue intestinal injury and stimulate intestinal regeneration in necrotizing enterocolitis (NEC)....
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Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway
BackgroundHypoxia is associated with many respiratory diseases, partly due to the accumulation of edema fluid and mucus on the surface of alveolar...
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HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing
BackgroundSmall airway remodelling is a vital characteristic of chronic obstructive pulmonary disease (COPD), which is mainly caused by epithelial...
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NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and...
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IRAK-M has effects in regulation of lung epithelial inflammation
BackgroundEpithelial barrier is important for asthma development by sha** immune responses. Airway expressing-IL-1 receptor-associated kinase...
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Robot versus video-assisted thoracoscopic thymectomy for large thymic epithelial tumors: a propensity-matched analysis
BackgroundBoth video-assisted thoracoscopic surgery (VATS) thymectomy and robot-assisted thoracoscopic surgery (RATS) thymectomy have been suggested...
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A CT-based radiomics nomogram involving the cystic fluid area for differentiating appendiceal mucinous neoplasms from appendicitis with intraluminal fluid
ObjectiveTo develop and validate a radiomics nomogram based on computed tomography (CT) to distinguish appendiceal mucinous neoplasms (AMNs) from...
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TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells
PurposeMechanosensitive channels (MSCs) and primary cilium possess a possible relevance for the sensation of intraocular pressure (IOP). However,...
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Evolution of demarcation line after pneumatic retinopexy—a case report
BackgroundDemarcation line in a rhegmatogenous retinal detachment (RD) is a classic finding noted in chronic cases. In this case report, we describe...
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Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury
BackgroundRadiation-induced lung injury (RILI) is the most common and serious complication of chest radiotherapy. However, reported radioprotective...
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Evaluating photodynamic therapy versus brolucizumab as a second-line treatment for polypoidal choroidal vasculopathy
BackgroundTo compare the one-year outcomes between intravitreal brolucizumab (IVBr) monotherapy and photodynamic therapy (PDT) as a second-line...
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An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
BackgroundAsthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develo** drugs that...
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Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral aspects of the breast...
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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope...
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RAGE inhibition alleviates lipopolysaccharides-induced lung injury via directly suppressing autophagic apoptosis of type II alveolar epithelial cells
BackgroundAdvanced glycation end product receptor (RAGE) acts as a receptor of pro-inflammatory ligands and is highly expressed in alveolar...
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The effect of combining an inhaled corticosteroid and a long-acting muscarinic antagonist on human airway epithelial cells in vitro
BackgroundAirway epithelial cells (AECs) are a major component of local airway immune responses. Direct effects of type 2 cytokines on AECs are...
