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Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis
Purpose of ReviewFibrosis is a pathological feature of many human diseases that affect multiple organs. The development of anti-fibrotic therapies...
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Polymeric immunoglobulin receptor (pIgR) in cancer
BackgroundThe polymeric immunoglobulin receptor (pIgR) is a transmembrane transporter of polymeric IgA through the intestinal epithelium. Its...
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Transcriptome-guided resolution of tumor microenvironment interactions in pheochromocytoma and paraganglioma subtypes
BackgroundPheochromocytomas and paragangliomas (PCPG) are rare catecholamine-secreting endocrine tumors deriving from chromaffin cells of the...
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Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake
The microenvironment of distant organ plays vital roles in regulating tumor metastases. However, little is known about the crosstalk between...
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Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway
PurposeChoroidal melanoma (CM), a kind of malignant tumor, is the main type of Uveal melanoma and one half of CM patients develop metastases. As a...
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Targeting EFNA1 suppresses tumor progression via the cMYC-modulated cell cycle and autophagy in esophageal squamous cell carcinoma
PurposeEsophageal squamous cell carcinoma (ESCC) remains one of the most common causes of cancer death due to the lack of effective therapeutic...
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New Diagnostic Biomarker-Soluble Erythropoietin-producing hepatocellular receptor A2 (EphA2) for colon cancer
To evaluate the association between soluble erythropoietin-producing hepatocellular receptor A 2 (EphA 2 ) levels and the patients’ tumor stage, tumor...
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Tracing the origins of glioblastoma by investigating the role of gliogenic and related neurogenic genes/signaling pathways in GBM development: a systematic review
BackgroundGlioblastoma is one of the most aggressive tumors. The etiology and the factors determining its onset are not yet entirely known. This...
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Angiogenic signaling pathways and anti-angiogenic therapy for cancer
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- and anti-angiogenic molecules, which...
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Evolution of clinical and translational advances in the management of pediatric arteriovenous malformations
Arteriovenous malformations (AVMs) represent one of the most challenging diagnoses in pediatric neurosurgery. Until recently, the majority of AVMs...
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Hallmarks of peripheral nerve function in bone regeneration
Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and...
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Neuronal guidance proteins in cardiovascular inflammation
Cardiovascular pathologies are often induced by inflammation. The associated changes in the inflammatory response influence vascular endothelial...
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Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases
BackgroundsNeuronal guidance proteins (NGPs) have been demonstrated to guide the elongation of neuronal axonal growth cones in the develo** central...
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Molecular and genetic mechanisms in brain arteriovenous malformations: new insights and future perspectives
Brain arteriovenous malformations (bAVMs) are rare vascular lesions made of shunts between cerebral arteries and veins without the interposition of a...
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Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cholangiocarcinoma
Intrahepatic mucinous cholangiocarcinoma (IHMC) is rare and behaves notoriously; however, the details of the clinicopathological characteristics of...
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Targeting EphA2 in cancer
Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple...
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Hitting Epstein Barr virus where it hurts: computational methods exploration for siRNA therapy in alleviating Epstein Barr virus-induced multiple sclerosis
Multiple sclerosis (MS), an intricate neurological disorder, continues to challenge our understanding of the pivotal interplay between the immune...
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Oncogenic functions and therapeutic targeting of EphA2 in cancer
More than 25 years of research and preclinical validation have defined EphA2 receptor tyrosine kinase as a promising molecular target for clinical...
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MUC1 triggers lineage plasticity of Her2 positive mammary tumors
Aberrant overexpression of mucin 1 (MUC1) and human epidermal growth factor receptor 2 (HER2) are often observed in breast cancer. However, the role...
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Extra-cardiac collateral to an anomalous origin right coronary artery in a post-PTCA, post-CABG patient
In the context of collateral circulation of the heart, the role of extra-cardiac collateral arteries has been thought to be negligible. We present a...
