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Gene – maltreatment interplay in adult ADHD symptoms: main role of a gene–environment correlation effect in a Brazilian population longitudinal study
Childhood maltreatment correlates with attention-deficit/hyperactivity disorder (ADHD) in previous research. The interaction between ADHD genetic...
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Association between birth by caesarian section and anxiety, self-harm: a gene-environment interaction study using UK Biobank data
BackgroundLimited efforts have been paid to explore the underlying genetic mechanisms of birth by caesarian section (CS) affecting the risks of adult...
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Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process
The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless,...
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The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness
BackgroundSince 1997, research on Gulf War illness (GWI) has predominantly used 3 case definitions—the original Research definition, the CDC...
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Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children
BackgroundIL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on...
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Do gene–environment interactions have implications for the precision prevention of type 2 diabetes?
The past decades have seen a rapid global rise in the incidence of type 2 diabetes. This surge has been driven by diabetogenic environmental changes...
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Cohort-guided insights into gene–environment interactions in autism spectrum disorders
Prospective birth cohorts offer unprecedented opportunities to investigate the pathogenesis of complex disorders such as autism, in which...
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Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes...
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Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation
Purpose of ReviewThis review aims to analyse the currently reported gene-environment (G × E) interactions in genome-wide association studies (GWAS),...
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Maternal depressive symptoms and children’s cognitive school readiness: the role of gene-environment interplay
Maternal depressive symptoms are a robust risk factor for poor cognitive outcomes in children, yet the role of gene-environment interplay in this...
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Dissecting schizophrenia phenotypic variation: the contribution of genetic variation, environmental exposures, and gene–environment interactions
Schizophrenia is among the leading causes of disability worldwide. Prior studies have conclusively demonstrated that the etiology of schizophrenia...
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Gene-Environment Interactions for Cardiovascular Disease
Purpose of ReviewWe provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk...
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Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma
Purpose of ReviewAsthma is one of the most common chronic inflammatory airway diseases. Airway oxidative stress is defined as an imbalance between...
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Investigation of gene–environment interactions in relation to tic severity
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously...
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Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty
BackgroundObesity is an important cause for the precocious or early puberty. However, the association between obesity-related loci and the risk of...
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Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments
Gene-environment interactions (GxE) are often suggested to play an important role in the aetiology of psychiatric phenotypes, yet so far, only a...
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Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene–environment interaction analysis in UK Biobank cohort
IntroductionSerum urate is associated with BMD and may be a protective factor. However, the exact association and mechanism are still unclear. We...
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UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice
The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly...
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Preterm birth and genitourinary tract infections: assessing gene–environment interaction
BackgroundPreterm birth (PTB) is the leading cause of perinatal morbimortality worldwide. Genetic and environmental factors could raise PTB risk. The...
