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Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids
Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood. While...
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Capillary leak and endothelial permeability in critically ill patients: a current overview
Capillary leak syndrome (CLS) represents a phenotype of increased fluid extravasation, resulting in intravascular hypovolemia, extravascular edema...
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Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability,...
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Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease
BackgroundKawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been...
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The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model
BackgroundEndothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with...
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Mafosfamide, a cyclophosphamide analog, causes a proinflammatory response and increased permeability on endothelial cells in vitro
Post-transplantation cyclophosphamide (PTCy) has decreased GVHD incidence. Endothelial damage in allo-HCT is caused by multiple factors, including...
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TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination
BackgroundDiabetic retinopathy (DR) as a severe diabetic complication contributes to blindness. The increased permeability of retinal capillary...
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Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes
BackgroundDiabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular...
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The glycocalyx as a permeability barrier: basic science and clinical evidence
Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability...
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Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders
Although there is convergent evidence for blood-brain barrier (BBB) dysfunction and peripheral inflammation in schizophrenia (SZ) and bipolar...
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Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP)....
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Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal...
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Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet
ObjectiveEndothelial dysfunction is one candidate for triggering neointima formation after arteriovenous grafts (AVGs), but the factors mediating...
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Flow-induced reprogramming of endothelial cells in atherosclerosis
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral artery disease continue to be leading causes of death...
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In vivo assessment of endothelial permeability of coronary lesions with variable degree of stenosis using an albumin-binding MR probe
MR imaging with an albumin-binding probe enables the visualization of endothelial permeability and damage in the arterial system. The goal of this...
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Endothelial cells and macrophages as allies in the healthy and diseased brain
Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequently both. Consequently,...
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Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Comment
In this letter to the Editor, the author reports his comment on the review article entitled “Gut microbiota, intestinal permeability, and systemic...
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Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
BackgroundIn acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics....
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Association between vascular endothelial growth factor-mediated blood–brain barrier dysfunction and stress-induced depression
Several lines of evidence suggest that stress induces the neurovascular dysfunction associated with increased blood–brain barrier (BBB) permeability,...
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The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which leads to microangiopathy and macroangiopathy and ultimately...
