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Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy
BackgroundThere is room for improvement of prevention of venous thromboembolism (VTE) after lower-leg cast application or knee arthroscopy....
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Sex-dependent balance between thrombin and plasmin generation in the presence of thrombomodulin
Background: Assessing simultaneous generation of thrombin (TG) and plasmin (PG) is an approach to evaluate the balance between coagulation and...
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Emicizumab-mediated hemostatic function assessed by thrombin generation assay in an in vitro model of factor VIII-depleted thrombophilia plasma
Patients with hemophilia A (PwHA) may have concurrent deficiency of representative anticoagulant proteins, protein (P)C, PS, and antithrombin (AT),...
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Enhanced thrombin generation detected with ST-Genesia analyzer in patients with newly diagnosed multiple myeloma
The issue of how to identify newly diagnosed multiple myeloma (NDMM) patients requiring thromboprophylaxis remains unsolved. Several changes in...
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Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives
Purpose of the ReviewThrombotic risk assessment in antiphospholipid positive (aPL +) subjects is a major challenge, and the study of in vitro...
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Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
BackgroundThe current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based...
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Interaction between thrombin potential and age on early clinical outcome in patients hospitalized for COVID-19
Patients with Coronavirus Disease-2019 (COVID‐19) have haemostatic dysfunction and are at higher risk of thrombotic complications. Although age is a...
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The association of thrombin generation with bleeding outcomes in cardiac surgery: a prospective observational study
BackgroundCardiac surgery with cardiopulmonary bypass (CPB) is associated with coagulopathic bleeding. Impaired thrombin generation may be an...
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Titrated versus conventional anticoagulation management for thrombin generation in cardiac surgery: a randomized controlled trial
PurposeOptimal heparin titration during cardiopulmonary bypass (CPB) may reduce coagulation system activation and preserve hemostatic function...
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Thrombin Generation in Trauma Patients: How Do we Navigate Through Scylla and Charybdis?
Purpose of ReviewCoagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi,...
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Calibrated automated thrombogram II: removing barriers for thrombin generation measurements
BackgroundThrombin generation (TG) assessed by Calibrated Automated Thrombogram (CAT-I) reflects the overall capacity of plasma to generate thrombin,...
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Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19
Thrombin is a trypsin-like serine protease with multiple physiological functions. Its role in coagulation and thrombosis is well-established....
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Association of prothrombin time, thrombin time and activated partial thromboplastin time levels with preeclampsia: a systematic review and meta-analysis
BackgroundPreeclampsia (PE), an obstetric disorder, remains one of the leading causes of maternal and infant mortality worldwide. In individuals with...
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How to assess hypercoagulability in heparin-induced thrombocytopenia? Biomarkers of potential value to support therapeutic intensity of non-heparin anticoagulation
BackgroundIn case of heparin-induced thrombocytopenia (HIT), the switch to a non-heparin anticoagulant is mandatory, at a therapeutic dose. Such a...
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Prolonged α-thrombin-related activation and delayed active protein C-associated degradation confer mild phenotype in a patient with severe hemophilia A with F8 p.H118R
In hemophilia A, bleeding mostly correlates with factor VIII activity (FVIII:C), although some patients show discrepancy in bleeding severity and...
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Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus
Aims/hypothesisPeople with diabetes have an increased cardiovascular risk with an accelerated development of atherosclerosis and an elevated...
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A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Purpose of ReviewMajor Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, feelings of...
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Thrombin in the Activation of the Fluid Contact Phase in Patients with Hereditary Angioedema Carrying the F12 P.Thr309Lys Variant
Hereditary angioedema due to pathogenic FXII variants (HAE-FXII) is a rare dominant disease caused by increased activation of the plasma contact...
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A modified thrombin generation assay to evaluate the plasma coagulation potential in the presence of emicizumab, the bispecific antibody to factors IXa/X
Emicizumab shortens activated partial thromboplastin time (aPTT) greater than Factor (F)VIII. Clot waveform analysis triggered by ellagic acid and...
