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Tumorinfiltrierende T-Zellen und natürliche Killerzellen im Melanom
Melanoma is a highly immunogenic cancer with an increased infiltration of lymphocytes (TIL). TIL are a very heterogeneous population which consists...
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Immunpathogenese des systemischen Lupus erythematodes
Insights into the immunopathogenesis of systemic lupus erythematosus (SLE) help to understand the complex disease patterns and to develop new...
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Neue Entwicklungen in der Immunonkologie
The development of checkpoint inhibition and chimeric antigen receptors (CAR) marks not the end but the beginning of an unprecedented innovation...
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CAR-T-Zell-Therapie bei Kindern und Jugendlichen mit akuter lymphatischer Leukämie
BackgroundAcute lymphatic leukemia is the most common malignant disease in children. Despite a good prognosis, new therapeutic concepts are needed...
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Erweitertes Verständnis von Pathogenese und Therapie der Kontaktallergie
BackgroundWhile the pathogenesis of contact allergy in recent years has increasingly focused on the mechanisms of the innate immune response, valid...
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Stellenwert von interleukingerichteten Therapien bei Autoimmunkrankheiten
Understanding the pathophysiology of autoimmune diseases enables the identification of new targets for more precise pharmacotherapies. Ideally, these...
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Aktuelle immuntherapeutische Ansätze beim multiplen Myelom
Antibodies against CD38 (cluster of differentiation 38) and SLAMF7 (signaling lymphocytic activation molecule F7) have been approved for the...
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Effektor-Memory-T‑Zellen in der Pathogenese von ANCA-assoziierten Vaskulitiden
Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral...
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