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Management of Localized Melanoma in the Anti-PD-1 Era
Purpose of ReviewThe management of cutaneous melanoma has rapidly progressed over the past decade following the introduction of effective systemic...
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Role of Concurrent Ultrasound Surveillance of Sentinel Node-Positive Node Fields in Melanoma Patients Having Routine Cross-Sectional Imaging
PurposeIn sentinel node-positive (SN+ve) melanoma patients, active surveillance with regular ultrasound examination of the node field has become...
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Surgical Management of Axilla of Triple-Negative Breast Cancer in the Z1071 Era: A Propensity Score-Matched Analysis of the National Cancer Database
BackgroundThe role of sentinel lymph node biopsy (SLNB) in triple-negative breast cancer (TNBC) patients who present with clinical N1 (cN1) disease...
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Evaluation of the Indications for Sentinel Node Biopsy in Early-Stage Melanoma with the Advent of Adjuvant Systemic Therapy: An International, Multicenter Study
BackgroundPatients presenting with early-stage melanoma (AJCC pT1b-pT2a) reportedly have a relatively low risk of a positive SNB (~5–10%). Those...
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Surgical Management of the Axilla of HER2+ Breast Cancer in the Z1071 Era: A Propensity-Score-Matched Analysis of the NCDB
IntroductionWe aim to analyze survival outcomes for sentinel lymph node biopsy (SLNB) versus axillary lymph node dissection (ALND) in human epidermal...
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Early posterior vault distraction osteogenesis changes the syndromic craniosynostosis treatment paradigm: long-term outcomes of a 23-year cohort study
BackgroundEarly surgical management of syndromic craniosynostosis varies widely between centers, with patients typically undergoing multiple...
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A retrospective comparison of Sun’s tip-flexible semirigid ureterorenoscopy, super-mini percutaneous nephrolithotomy and flexible ureteroscopy applied to treat upper urinary tract calculi
BackgroundThis retrospective study was conducted to compare the safety and efficacy of Sun’s tip-flexible semirigid ureterorenoscopy (tf-URS),...
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Reversible large-scale network disruption correlates with neurocognitive improvement in HIV-associated minor neurocognitive disorder with combined anti-retroviral therapy intensification: a prospective longitudinal resting-state functional magnetic resonance imaging study
ObjectiveHIV-associated neurocognitive disorder (HAND) affects multiple cognitive domains and currently, the neuropsychological testing is the gold...
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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial
Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT)...
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Photoactive metabolite mediated photodynamic therapy of Rhabdomyosarcoma cell lines using medicinal plants and Doxorubicin co-treatments
BackgroundMedicinal plant-mediated combinational therapies have gained importance globally due to minimal side effects and enhanced treatment...
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Contributions of the UK biobank high impact papers in the era of precision medicine
To review the highest impact studies published from the UK Biobank and assess their contributions to “precision medicine.” We reviewed 140 of 689...
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Emerging Applications of Artificial Intelligence in Dermatopathology
Purpose of ReviewArtificial intelligence (AI) is revolutionizing health care – transforming how physicians evaluate, diagnose, and manage a wide...
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Pharmacogenomics in IVF: A New Era in the Concept of Personalized Medicine
Pharmacogenomics is a promising approach in the field of individualized medicine in in vitro fertilization (IVF) treatment that aims to develop...
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Shenmai Injection Attenuates Myocardial Ischemia/Reperfusion Injury by Targeting Nrf2/GPX4 Signalling-Mediated Ferroptosis
ObjectiveTo examine the effect of Shenmai Injection (SMJ) on ferroptosis during myocardial ischemia reperfusion (I/R) injury in rats and the...
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Axillary Management: How Much Is Too Much?
Purpose of ReviewTo review the current management of the axilla in breast cancer.
Recent FindingsAxillary dissection is no longer indicated in...
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Dynamic resectorization to improve utility of healthcare systems
Balancing is an essential challenge in healthcare systems that requires effective strategies. This study aims to address this crucial issue by...
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Corticosteroids in COVID-19: Is it Rational? A Systematic Review and Meta-Analysis
Due to a lack of definitive treatment, many drugs were repurposed for Coronavirus disease (COVID-19) treatment; among them, corticosteroid is one....
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Indian Academy of Pediatrics Consensus Statement on Diagnosis and Management of Bone and Joint Infections in Children
JustificationOsteoarticular infections are fairly common in children but often these are associated with underdiagnosis, delayed diagnosis and...