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Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine...
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Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year-old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?
Immune checkpoint inhibitors (ICIs) are drugs growingly employed in cancer immunotherapy which have significantly improved the prognosis of several...
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Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
ObjectivesThis study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE),...
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Immune mechanisms in the pathophysiology of hypertension
Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, most individuals with...
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Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression
Postpartum depression (PPD) is a leading cause of morbidity and mortality among women. Clinically, the administration and withdrawal of...
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Targeting the innate immune system in pediatric and adult AML
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult...
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Emerging mechanisms of obesity-associated immune dysfunction
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus, cardiovascular disease, hypertension and nonalcoholic...
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Subtypes of schizophrenia identified by multi-omic measures associated with dysregulated immune function
Epigenetic modifications are plausible molecular sources of phenotypic heterogeneity across schizophrenia patients. The current study investigated...
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Multi-omics analysis reveals overactive inflammation and dysregulated metabolism in severe community-acquired pneumonia patients
BackgroundSevere community-acquired pneumonia (S-CAP) is a public health threat, making it essential to identify novel biomarkers and investigate the...
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The role of the immune system in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological...
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Vitamin D, the immune system, and its relationship with diseases
BackgroundVitamin D is classified as an immunomodulatory hormone that is synthesized because of skin exposure to sunlight. It is known to come into...
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Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for develo** effective treatments....
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Tobacco and menthol flavored nicotine-free electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium
BackgroundElectronic cigarette (e-cig) va** has increased in the past decade in the US, and e-cig use is misleadingly marketed as a safe cessation...
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Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system and fibrosis in the skin and...
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A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model
Immune dysregulation plays a key role in the pathogenesis of autism. Changes occurring at the systemic level, from brain inflammation to disturbed...
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RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface
BackgroundUterine adenomyosis is associated with chronic pelvic pain, abnormal uterine bleeding, and infertility. The pathogenesis of adenomyosis is...
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Structural and functional connections between the autonomic nervous system, hypothalamic–pituitary–adrenal axis, and the immune system: a context and time dependent stress response network
The autonomic nervous system (ANS), hypothalamic–pituitary–adrenal (HPA) axis, and immune system are connected anatomically and functionally. These...
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Immune urinary biomarkers predict infant cardiac surgery-associated acute kidney injury
BackgroundAcute kidney injury (AKI) occurs frequently after infant cardiac surgery and is associated with poor outcomes, including mortality and...
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Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice
Schizophrenia (SCZ), as a neurodevelopmental disorder and devastating disease, affects approximately 1% of the world population. Although numerous...
