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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere...
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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the...
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Targeting epigenetic regulators to overcome drug resistance in cancers
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions...
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The Critical Role of Biomarkers for Drug Development Targeting the Biology of Aging
Alzheimer’s disease is a devastating neurodegenerative disorder that poses a significant societal burden. Approval of anti-amyloid antibody therapies...
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A microCT-based platform to quantify drug targeting
BackgroundHeterotopic ossification (HO) is a frequent and debilitating complication of traumatic musculoskeletal injuries and orthopedic procedures....
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Targeting Mesothelin in Solid Tumours: Anti-mesothelin Antibody and Drug Conjugates
Purpose of ReviewThis review aims to summarise the pathobiological role of mesothelin and the current data on therapeutic antibodies targeting...
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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1
ObjectiveRetinoblastoma (RB) is a prevalent type of eye cancer in youngsters. Prospero homeobox 1 (Prox1) is a homeobox transcriptional repressor and...
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A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new...
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Recent advances in develo** active targeting and multi-functional drug delivery systems via bioorthogonal chemistry
Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic...
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New Drug Delivery Systems Developed for Brain Targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (B CSF ) are two of the most complex and sophisticated concierges that defend...
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Targeting small druggable compounds against 3RZE histamine H1 receptor as potential of anti-allergic drug applying molecular modeling approach
BackgroundAllergic disorders, prevalent global health concerns, afflict a substantial portion of the world’s population. These maladies result from...
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Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor
BackgroundGastrointestinal stromal tumor (GIST) is a rare type of cancer that occurs in the gastrointestinal tract. The majority of GIST cases carry...
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Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours
BackgroundIn recent years, the field of nanotechnology and nanomedicine has transformed the pharmaceutical industry with the development of novel...
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Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
A drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of the drug to one or more...
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Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs
Metastatic cancer remains incurable as patients eventually loose sensitivity to targeted therapies and chemotherapies, further leading to poor...
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Targeting Interferon Signalling in Systemic Lupus Erythematosus: Lessons Learned
The development of new medicines for systemic lupus erythematosus (SLE) has not addressed unmet clinical need, with only three drugs receiving...
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
ObjectivesTo assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse...
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Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway
PurposeAcute myeloid leukemia (AML) is a refractory hematologic malignancy that poses a serious threat to human health. Exploring alternative...
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Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N 6 methyladenosine (m 6 A) modification is closely involved in physiological processes, such...
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Emulsomes: new lipidic carriers for drug delivery with special mention to brain drug transport
BackgroundEmulsomes are a type of lipid-based nanoparticle that consists of a solid lipid core surrounded by a phospholipid bilayer and have shown...
