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Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma
BackgroundGlioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge....
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Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular...
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Enriching limited information on rare diseases from heterogeneous networks for drug repositioning
BackgroundThe historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great...
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Drug Repurposing for Emerging Infectious Diseases and Cancer
This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silicoapproaches for...
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A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with few effective therapeutic options. Recently, drug repositioning,...
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Repositioning synthetic glucocorticoids in psychiatric disease associated with neural autoantibodies: a narrative review
Synthetic glucocorticoids (sGCs) are a well-investigated and standard drug therapy for disorders associated with CNS inflammation. Less is known...
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The effects of exercise training on knee repositioning sense in people with knee osteoarthritis: a systematic review and meta-analysis of clinical trials
ObjectiveOsteoarthritis (OA) of the knee is one of the most common global joint disorders, especially in aging population, and is among leading...
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An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the...
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Drug repositioning and repurposing for Alzheimer disease
Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for...
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Integrated systems biology analysis of acute lymphoblastic leukemia: unveiling molecular signatures and drug repurposing opportunities
Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by aberrant proliferation and accumulation of lymphoid precursor cells...
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A computational multi-targeting approach for drug repositioning for psoriasis treatment
BackgroundPsoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed...
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Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma
Objectives Malignant pleural mesothelioma (MPM) is an occupational disease mainly due to asbestos exposure. Effective therapies for MPM are lacking,...
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Drug repositioning for psychiatric and neurological disorders through a network medicine approach
Psychiatric and neurological disorders (PNDs) affect millions worldwide and only a few drugs achieve complete therapeutic success in the treatment of...
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Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cancer cells in response to...
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Analysis and identification of drug similarity through drug side effects and indications data
BackgroundThe measurement of drug similarity has many potential applications for assessing drug therapy similarity, patient similarity, and the...
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Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder
BackgroundAsverin® (tipepidine hibenzate) has been used as an antitussive for > 50 years in Japan. Studies revealed that tipepidine modulates...
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Exploration of key drug target proteins highlighting their related regulatory molecules, functional pathways and drug candidates associated with delirium: evidence from meta-data analyses
BackgroundDelirium is a prevalent neuropsychiatric medical phenomenon that causes serious emergency outcomes, including mortality and morbidity. It...
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A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties
Alternative splicing of the vascular endothelial growth factor A ( VEGF-A ) terminal exon generates two protein families with differing functions....
