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Bile Acid Malabsorption in Patients with Neuroendocrine Tumors
BackgroundChronic diarrhea in patients with neuroendocrine tumors (NET) may be caused by bioactive products of NET, bile acid malabsorption (BAM),...
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Anti-coagulant Treatment of Cancer-Associated Thrombosis in Frail Patients: Impact of Frailties on the Management of Drug–Drug Interactions
Low molecular weight heparins (LMWH) and anti-Xa direct oral anti-coagulants (DOACs) are recommended for the long-term treatment of cancer-associated...
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Prevalence of biliary acid malabsorption in patients with chronic diarrhoea of functional characteristics: a prospective study
BackgroundBile acid malabsorption occurs in up to one third of patients with chronic diarrhoea of functional characteristics. The gold standard test...
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Maldigestion Versus Malabsorption in the Elderly
Purpose of ReviewTo evaluate recently published information about the frequency of maldigestion and malabsorption in older individuals, likely...
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Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism
Background and ObjectiveEsmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of...
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The Critical Intersect of Regulations, Health Technology Assessment, and Drug Safety Assessments
Health technology assessment (HTA) is a multidisciplinary process that determines the value of health technology at different points in its...
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Endothelial dysfunction is associated with reduced myocardial mechano-energetic efficiency in drug-naïve hypertensive individuals
Impaired myocardial mechano-energetics efficiency (MEE) was shown to predict incident heart failure, but pathophysiological mechanisms linking...
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Levothyroxine absorption test followed by directly observed treatment on an outpatient basis to address long-term high thyrotropin levels in a hypothyroid patient: a case report
BackgroundFor the treatment of hypothyroidism, patients are usually placed on lifelong levothyroxine replacement therapy. Achieving clinical and...
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Hippocampal sclerosis is associated with celiac disease type immunity in patients with drug-resistant temporal lobe epilepsy
BackgroundA prior small-scale single center study suggested an association between celiac disease (CD)-type immunity and refractory temporal lobe...
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Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review
ObjectiveThe purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to...
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Novel Drug Therapeutics in Celiac Disease: A Pipeline Review
Celiac disease (CeD) is a chronic, autoimmune systemic disorder triggered by the ingestion of gluten, a protein found in foods such as wheat, rye,...
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Prophylaxis of hepatic encephalopathy: current and future drug targets
Hepatic encephalopathy is described by a broad spectrum of neurological and psychiatric aberrations resulting due to advanced liver dysfunction. It...
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GRADE-ADOLOPMENT of clinical practice guideline for postmenopausal osteoporosis management—a Pakistani context
SummaryDue to its high prevalence, we aimed to create postmenopausal osteoporosis clinical practice guideline via GRADE-ADOLOPMENT for Pakistan. We...
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Therapeutic Drug Monitoring in Non-Tuberculosis Mycobacteria Infections
Nontuberculous mycobacteria can cause minimally symptomatic self-limiting infections to progressive and life-threatening disease of multiple organs....
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Expert consensus on drug treatment of chronic subdural hematoma
Chronic subdural hematoma (CSDH) is a chronic space-occupying lesion formed by blood accumulation between arachnoid and dura mater, which is usually...
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Frequency and prognostic impact of cachexia during drug treatment for unresectable advanced gastric cancer patients
PurposePatients with unresectable advanced metastatic gastric cancer have a poor prognosis. This study examined the incidence and prognostic impact...
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Metabolomics and lipidomics signature in celiac disease: a narrative review
Celiac disease (CD) is a chronic immune-mediated inflammatory disease of the small intestine caused by aberrant immune responses to consumed gluten...
