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A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription
The essential G 1 -cyclin, CCND1 , is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type...
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Nuclear transport proteins: structure, function, and disease relevance
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental...
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Craving for carbs: food craving and disordered eating in low-carb dieters and its association with intermittent fasting
Studies point to positive outcomes in a diet with reduction of carbohydrates and that the associated practice of intermittent fasting (IF) might...
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Regulation of Src tumor activity by its N-terminal intrinsically disordered region
The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src...
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An immunoinformatics approach for design and validation of multi-subunit vaccine against Plasmodium falciparum from essential hypothetical proteins
Malaria, caused by Plasmodium falciparum , remains a pressing global health concern. Advancements in combating this parasite involve the development...
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Causal association between cardiovascular proteins and membranous nephropathy: a bidirectional Mendelian randomization
PurposeMultiple circulating proteins have been reported to participate in human diseases. However, the association between cardiovascular proteins...
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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere...
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Alternative splicing and related RNA binding proteins in human health and disease
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein...
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Disordered eating and eating disorders among women seeking fertility treatment: A systematic review
The purpose of this systematic review is to evaluate the prevalence of disordered eating and eating disorders among women seeking fertility treatment.
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Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels
BackgroundAtrial fibrillation (AF) is associated with circulating inflammation. Short-chain fatty acids (SCFAs) derived from gut microbiota (GM)...
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Altered microbiota caused by disordered gut motility leads to an overactivation of intestinal immune system in APC1638T mice
Adenomatous polyposis coli ( APC ) is recognized as an antioncogene related to familial adenomatous polyposis and colorectal cancers. However, APC is a...
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Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats
PurposeThe effects of calorie restriction (CR) on gut microbiota and the mechanism of CR ameliorating hyperglycemia in streptozotocin (STZ)-induced...
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Research progress on exosomal proteins as diagnostic markers of gastric cancer (review article)
Gastric cancer (GC) is one of the most common types of tumors and the most common cause of cancer mortality worldwide. The diagnosis of GC is...
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Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother–child interaction
PurposeEating disturbances are complex heritable conditions that can be influenced by both genetic and environmental factors but are poorly studied...
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Comparative evaluation of acute phase proteins by C-reactive protein (CRP) and serum amyloid A (SAA) in nonhuman primates and feline carnivores
The feasibility of a commercially available assay for C-reactive protein (CRP, CRP for humans: hCRP, and CRP for dogs: vCRP) and a trial reagent of...
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RNA-binding proteins and their role in kidney disease
RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene regulation and protein synthesis. They are required for...
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Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters;...
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“Good food equals good health”: a focus group study of adolescent boys’ perceptions of eating and weight
BackgroundDisordered eating refers to unhealthy, sometimes excessive eating including so-called compensatory behaviours such as extreme dieting or...
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A novel strategy for develo** vaccine candidate against Jaagsiekte sheep retrovirus from the envelope and gag proteins: an in-silico approach
BackgroundSheep pulmonary adenocarcinoma (OPA) is a contagious lung cancer of sheep caused by the Jaagsiekte retrovirus (JSRV). OPA typically has a...
