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Clinical, echocardiographic and prognostic outcomes of patients with concordant and discordant high-gradient aortic stenosis in an Asian cohort
Literature of patients with severe high-gradient aortic stenosis (HG AS) (mean pressure gradient [MPG] ≥ 40 mmHg and aortic valve area [AVA] ≥ 1.0 cm 2 ...
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Candidate biomarkers from the integration of methylation and gene expression in discordant autistic sibling pairs
While the genetics of autism spectrum disorders (ASD) has been intensively studied, resulting in the identification of over 100 putative risk genes,...
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Impact of stroke volume assessment by three-dimensional transesophageal echocardiography on the classification of low-gradient aortic stenosis
BackgroundAccurate assessment of flow status is crucial in low-gradient aortic stenosis (AS). However, the clinical implication of three-dimensional...
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Severe low-gradient aortic stenosis: impact of inadequate left ventricular responses to high afterload on diagnosis and therapeutic decision-making
The fact that nearly 50% of patients with an aortic valve (AV) area < 1.0 cm 2 , consistent with severe aortic stenosis (AS), can have mean trans-AV...
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Aortic valve calcium volume as measured by native versus contrast-enhanced computer tomography and the implications for the diagnosis of severe aortic stenosis in TAVR patients with low-gradient aortic stenosis
BackgroundMost of TAVR centers evaluate the calcium score in contrast-enhanced (ce) CT. We compared in this study between different methodologies to...
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Fracture risk gradient assessed by categories of bone mineral density and trabecular bone score: the Manitoba BMD Registry
SummaryTrabecular bonescore (TBS) helps to predict fracture risk in older adults. In this registry-based cohort study of patients aged 40 years and...
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Anterior gradient proteins in gastrointestinal cancers: from cell biology to pathophysiology
Most of the organs of the digestive tract comprise secretory epithelia that require specialized molecular machines to achieve their functions. As...
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Echocardiography and EuroSCORE II for the stratification of low-gradient severe aortic stenosis and preserved left ventricular ejection fraction
The purpose of this study was to explore the utility of echocardiography and the EuroSCORE II in stratifying patients with low-gradient severe aortic...
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The diagnostic role of “acceleration time” measurement in patients with classical low flow low gradient aortic stenosis with reduced left ventricular ejection fraction
PurposeIn our study, we aimed to assess the role of acceleration time (AT), ejection time (ET), and AT/ET ratio to distinguish between true and...
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Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight
BackgroundObesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2...
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Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly...
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Reproducibility and intratumoral heterogeneity of the PAM50 breast cancer assay
BackgroundThe PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how...
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miRNA expression profile changes in the peripheral blood of monozygotic discordant twins for epithelial ovarian carcinoma: potential new biomarkers for early diagnosis and prognosis of ovarian carcinoma
BackgroundOvarian cancer is the second most common gynecologic cancer with high mortality rate and generally diagnosed in advanced stages. The 5-year...
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Impact of surgical aortic valve replacement on global and regional longitudinal strain across four flow gradient patterns of severe aortic stenosis
To evaluate the impact of surgical aortic valve replacement (SAVR) on global (GLS) and regional longitudinal strain (RLS) across four flow-gradient...
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Impact of right ventricular stiffness on discordance between hemodynamic parameter and regurgitant volume in patients with pulmonary regurgitation
Background : Accurate detection of significant pulmonary regurgitation (PR) is critical in management of patients after right ventricular (RV) outflow...
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Impact of stenosis resistance and coronary flow capacity on fractional flow reserve and instantaneous wave-free ratio discordance: a combined analysis of DEFINE-FLOW and IDEAL
BackgroundThe pressure-derived parameters fractional flow reserve (FFR) and the emerging instantaneous wave-free ratio (iFR) are the most widely...
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Gut health of horses: effects of high fibre vs high starch diet on histological and morphometrical parameters
BackgroundThe conventional feeding management of horses is still characterized by high starch and low fibre diets, which can negatively affect...
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Calcium Scoring to Classify Aortic Valve Stenosis Severity: What Is the Current Data?
Purpose of ReviewThis review explores current clinical value of aortic valve calcification (AVC) in classifying aortic valve stenosis (AS) severity,...
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Low Gradient Aortic Stenosis: Role of Echocardiography
Purpose of ReviewThe purpose of this paper is to review the current role of echocardiography in the evaluation of patients with low gradient severe...
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Updates to a Modern Dilemma: a Practical Approach to the Workup and Management of Low-Gradient Severe Aortic Stenosis Using Transvalvular Flow Rate
Purpose of reviewTo provide a new and practical approach for clinicians assessing and managing patients with low-gradient severe aortic stenosis (AS)...
