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Implementation of a rapid diagnostic assay package for cryptococcosis, histoplasmosis and tuberculosis in people living with HIV in Paraguay
BackgroundOpportunistic infections (OIs) are common causes of mortality among people living with HIV (PLHIV). We determined prevalence and 30-day...
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Implementation of evidence-based multiple focus integrated intensified TB screening to end TB (EXIT-TB) package in East Africa: a qualitative study
IntroductionTuberculosis (TB) remains a major cause of morbidity and mortality, especially in sub-Saharan Africa. We qualitatively evaluated the...
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Comparison for the diagnostic performance of early diagnostic methods for biliary atresia: a systematic review and network meta-analysis
BackgroundBiliary atresia (BA), a progressive condition affecting canalicular-bile duct function/anatomy, requires prompt surgical intervention for...
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Construction and evaluation of immune-related diagnostic model in patients with heart failure caused by idiopathic dilated cardiomyopathy
ObjectiveThe purpose of the study was to construct the potential diagnostic model of immune-related genes during the development of heart failure...
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Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease
BackgroundChronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it is identified early and managed...
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A collaborative care package for depression comorbid with chronic physical conditions in South Africa
IntroductionA task-sharing collaborative care model for integrated depression care for South Africa’s burgeoning primary health care population with...
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How Does the Visual Function and Glaucoma-Related Quality of Life Vary After an Educational Intervention?
Maintaining quality of life among individuals suffering from glaucoma should be accounted as the most significant purpose for management of the...
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Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer using bulk and single-cell RNA sequencing technology
BackgroundCharacterizing tumor microenvironment using single-cell RNA sequencing has been a promising strategy for cancer diagnosis and treatment....
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Diagnostic delay in psoriatic arthritis: insights from a nationwide multicenter study
This study aimed to investigate the duration of diagnostic delay in patients with psoriatic arthritis (PsA) and identify potential contributing...
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Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow — protocol for the OPTimisE pilot and feasibility randomised controlled trial
BackgroundPhysiotherapy is recommended for people with tennis elbow, but whilst a wide array of treatments is available, the optimal approach remains...
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Diagnostic biomarkers for ST-segment elevation myocardial infarction using RNA methylation regulators
AimsAdditional evidence has indicated a correlation between N6-methyladenosine (m6A) RNA methylation and cardiovascular disease. Nevertheless, the...
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Is deployement of diagnostic test alone enough? Comprehensive package of interventions to strengthen TB laboratory network: three years of experience in Burkina Faso
BackgroundsThe laboratory plays a critical role in tuberculosis (TB) control by providing testing for diagnosis, treatment monitoring, and...
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Diagnostic shift in adolescents with first episode psychosis: findings from the 2-year follow-up of the “Parma Early Psychosis” program
PurposeDiagnostic stability for people with First Episode Psychosis (FEP) is essential for treatment, but it remains poorly investigated, especially...
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Bronchopulmonary dysplasia: analysis and validation of ferroptosis-related diagnostic biomarkers and immune cell infiltration features
BackgroundEarly and precise diagnosis of bronchopulmonary dysplasia (BPD) is essential to improve the prognosis of preterm infants with BPD. Studying...
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Impact of a package of diagnostic tools, clinical algorithm, and training and communication on outpatient acute fever case management in low- and middle-income countries: protocol for a randomized controlled trial
BackgroundThe management of acute febrile illnesses places a heavy burden on clinical services in many low- and middle-income countries (LMICs)....
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Adaptation, implementation, and evaluation of the HEARTS technical package in primary health care settings in Jordan to improve the management of hypertension: a pilot study
The majority of patients with hypertension in Jordan have uncontrolled blood pressure. This study aimed to adapt and implement the hypertension...
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Diagnostic delay of sarcoidosis: an integrated systematic review
BackgroundSarcoidosis is a chronic inflammatory granulomatous disease of unknown cause. Delays in diagnosis can result in disease progression and...
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A mHealth intervention to reduce perceived stress in patients with ischemic heart disease: study protocol of the randomized, controlled confirmatory intervention “mStress-IHD” trial
BackgroundStress is highly prevalent in patients with ischemic heart disease (IHD) and is associated with lower health-related quality of life and...
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Positive attitudes toward adoption of a multi-component intervention strategy aimed at improving HIV outcomes among adolescents and young people in Nampula, Mozambique: perspectives of HIV care providers
BackgroundService providers' attitudes toward interventions are essential for adopting and implementing novel interventions into healthcare settings,...
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Evaluating a multifaceted implementation strategy and package of evidence-based interventions based on WHO PEN for people living with HIV and cardiometabolic conditions in Lusaka, Zambia: protocol for the TASKPEN hybrid effectiveness-implementation stepped wedge cluster randomized trial
BackgroundDespite increasing morbidity and mortality from non-communicable diseases (NCD) globally, health systems in low- and middle-income...
