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Effects of Violet and IR LED Light on mast cell degranulation: in vivo study in a murine model
The aim of this study was to evaluate the influence of IR (λ850 ± 10 nm) and violet (λ405 ± 10 nm) LED phototherapy on total mast cells counts and...
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Expression and degranulation of mast cells in laser photobiomodulated mucositis chemo-induced: pilot study in hamsters
This study aimed to evaluate the influence of laser photobiomodulation on the expression and degranulation of mast cells in chemo-induced oral...
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SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate...
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Antiallergic activity of Skimmia anquetilia on ovalbumin-induced allergic rhinitis, dermatitis, paw oedema and mast cell degranulation
BackgroundAsthma, allergic rhinitis, acute dermatitis, allergic skin reactions, hypersensitivity reactions and other autoimmune illnesses remain...
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NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH), particularly primary HLH (pHLH), is a rare, life-threatening disease. Germline genetic deficiency of 12...
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Neutrophil degranulation and severely impaired extracellular trap formation at the basis of susceptibility to infections of hemodialysis patients
BackgroundChronic kidney disease patients are at increased risk of mortality with cardiovascular diseases and infections as the two leading causes of...
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The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation
BackgroundAllergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments...
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Local (but not systemic) photobiomodulation treatment reduces mast cell degranulation, eicosanoids, and Th2 cytokines in an experimental model of allergic rhinitis
Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, and is a worldwide health problem with a significant impact on the quality of...
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Transcutaneous systemic photobiomodulation reduced lung inflammation in experimental model of asthma by altering the mast cell degranulation and interleukin 10 level
Asthma is a chronic inflammatory disease characterized by recurrent and reversible episodes of wheezing, dyspnea, chest stiffness, and cough. Its...
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Functional Dyspepsia and Duodenal Eosinophil Count and Degranulation: A Multiethnic US Veteran Cohort Study
BackgroundDuodenal eosinophilia may play a role in functional dyspepsia (FD), but existing study results are conflicted. We investigated the...
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Reduced frequency of cytotoxic CD56dim CD16+ NK cells leads to impaired antibody-dependent degranulation in EBV-positive classical Hodgkin lymphoma
Around 30–50% of classical Hodgkin lymphoma (cHL) cases in immunocompetent individuals from industrialized countries are associated with the...
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Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats
Herein, we report the influence of administering different protocols of preconditioned diabetic adipose-derived mesenchymal stem cells (ADSs) with...
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The effect of laparoscopy on mast cell degranulation and mesothelium thickness in rats
BackgroundLaparoscopy induces adhesion due to ischemia-reperfusion injury. However, the detail pathomechanism is poorly understood. This study aimed...
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Molecular analysis of the novel L243R mutation in STXBP2 reveals impairment of degranulation activity
The presence of mutations in PRF1, UNC13D, STX11 and STXBP2 genes in homozygosis or compound heterozygosis results in immune deregulation. Most such...
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Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages
Multiple myeloma (MM) is an incurable disease, characterized by malignant plasma cells in the bone marrow. MM growth is largely dependent on the...
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Human placental extract suppresses mast cell activation and induces mast cell apoptosis
BackgroundHuman placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of...
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Bifidobacteria modulate immune response in pediatric patients with cow’s milk protein allergy
BackgroundIn children with an allergy to cow’s milk proteins (CMA), the altered composition of intestinal microbiota influences the immune tolerance...
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Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy
Multiple myeloma (MM) is an incurable hematological cancer, in which immune checkpoint inhibition (ICI) with monoclonal antibodies (mAbs) has failed...
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Quisqualis indica Linn.: HRLCMS/MS profiling and anti-asthma activity of leaf extracts
BackgroundAsthma is a chronic inflammatory disorder of the airways, involving various cells and cellular elements precisely eosinophils, mast cells,...
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Evaluation of the innate immune response of caprine neutrophils against Mycobacterium avium subspecies paratuberculosis in vitro
Neutrophils constitute an essential component of the innate immune response, readily killing most bacteria through phagocytosis, degranulation, and...
