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Protein sequence analysis in the context of drug repurposing
MotivationDrug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery....
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Success rate of rapid DNA technology in kinship analysis for forensic purpose
Reducing the time required for DNA analysis in forensic genetics can yield significant benefits, both in determining genealogical relationships for...
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Genome-wide DNA methylation analysis related to ALS patient progression and survival
BackgroundEpigenetics contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). We aimed to characterize the DNA methylation profiles...
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Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins
BackgroundElevated fasting plasma glucose (FPG) levels can increase morbidity and mortality even when it is below the diagnostic threshold of type 2...
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Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence
BackgroundTransitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of...
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Identifying a suspect powder as a cannabis concentrate through chemical analysis and DNA testing
PurposeCannabis is regulated in many countries, and cannabis products are diversifying, which can hinder identification. Here, we report the seizure...
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Fulvestrant and everolimus efficacy after CDK4/6 inhibitor: a prospective study with circulating tumor DNA analysis
In a prospective study (NCT02866149), we assessed the efficacy of fulvestrant and everolimus in CDK4/6i pre-treated mBC patients and circulating...
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Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid
Detection of peritoneal dissemination (PD) in gastric cancer (GC) patients remains challenging. The feasibility of tumor-guided cell-free DNA (cfDNA)...
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Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation
Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these...
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Mitochondrial DNA sequence variation and risk of meningioma
BackgroundRisk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation....
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An integrated analysis of microRNAs regulating DNA damage response in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) remains a clinical challenge due to its aggressive phenotype and limited treatment options for the...
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Effects of solvent-based adhesive removal on the subsequent dual analysis of fingerprint and DNA
The combined approach of classical fingerprinting and DNA profiling is a powerful tool in forensic investigations of latent “touch” traces. However,...
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Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress–Induced-Sertoli Cells Apoptosis
The problem of male infertility is a global health crisis and poses a serious threat to the well-being of families. Under heat stress (HS), the...
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Genetic analysis of genome sequence characteristics of two lumpy skin disease viruses isolated from China
BackgroundLumpy skin disease (LSD) is an acute or subacute infectious disease caused by lumpy skin disease virus (LSDV) of genus Capripoxvirus . The...
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Diagnostic models to predict nuclear DNA and mitochondrial DNA recovery from incinerated teeth
Teeth are frequently used for human identification from burnt remains, as the structure of a tooth is resilient against heat exposure. The intricate...
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SNP analysis of challenging bone DNA samples using the HID-Ion AmpliSeq™ Identity Panel: facts and artefacts
PCR-MPS is an emerging tool for the analysis of low-quality DNA samples. In this study, we used PCR-MPS to analyse 32 challenging bone DNA samples...
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Characteristics of the a sequence of the duck Plague virus genome and specific cleavage of the viral genome based on the a sequence
During the replication process, the herpesvirus genome forms the head-to-tail linked concatemeric genome, which is then cleaved and packaged into the...
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The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PK
BRCA1-associated protein 1 (BAP1) has emerged as a major tumor suppressor gene in diverse cancer types, notably in malignant pleural mesothelioma...
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Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes
Frontotemporal lobar degeneration (FTLD) is an umbrella term describing the neuropathology of a clinically, genetically and pathologically...
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Multi-omics analysis of DNA replication-associated primase polymerase (PRIMPOL) in pan-cancer: a potential target for prognosis and immune response
BackgroundIt is critical to understand the mechanisms of human cancers in order to develop the effective anti-cancer therapeutic strategies. Recent...
