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Cytotoxic activity of essential oil from Leaves of Myrcia splendens against A549 Lung Cancer cells
BackgroundPlants of the Myrcia genus have been widely used in folk medicine to treat various diseases, including cancer. Myrcia splendens species...
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Cytotoxic activity of non-specific lipid transfer protein (nsLTP1) from Ajwain (Trachyspermum ammi) seeds
BackgroundTrachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse...
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D,L-Methadone enhances the cytotoxic activity of standard chemotherapeutic agents on pediatric rhabdomyosarcoma
PurposeIn advanced tumor stages, pediatric rhabdomyosarcoma (RMS) shows an intrinsic resistance to standard chemotherapy, which is associated with a...
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Phytochemical analysis and evaluation of its antioxidant, antimicrobial, and cytotoxic activities for different extracts of Casuarina equisetifolia
BackgroundCasuarina equisetifolia belongs to the Casuarina species with the most extensive natural distribution, which contain various...
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In vitro cytotoxic effect of stigmasterol derivatives against breast cancer cells
BackgroundStigmasterol is an unsaturated phytosterol that belong to the class of tetracyclic steroids abundant in Rhoicissus tridentata ....
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Targeting cytotoxic lymphocyte antigen 4 (CTLA-4) in breast cancer
Breast cancer (BC) has a high mortality rate and is one of the most common malignancies in the world. Initially, BC was considered non-immunogenic,...
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Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities
Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies, successfully used for decades, continue to transform the lives of...
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Favorable clinical efficacy of cytotoxic chemotherapy in patients with progressive desmoid tumors: a retrospective real-world study
BackgroundThe real-world evidence about the efficacy of cytotoxic chemotherapy in desmoid tumors is still limited. We investigated the efficacy of...
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Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy and improved survival in a growing number of cancers. Despite their success, ICIs are...
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Examining the effect of activated cytotoxic (CD8+) T-cell exosomes to the lung cancer
Lung cancer continues to be a major health problem worldwide owing to its incidence, and causes physical, psychological, social, and economic...
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Proteomic characterization and cytotoxic potential of proteins from Cuscuta (Cuscuta epithymum (L.) crude herbal product against MCF-7 human breast cancer cell line
BackgroundThe burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta , used in traditional...
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Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines
Acute myeloid leukemia is one of the most commonly identified hematological malignancies with poor prognosis. This research was planned to identify...
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Efficacy and safety evaluation of black ginseng (Panax ginseng C.A. Mey.) extract (CJ EnerG): broad spectrum cytotoxic activity in human cancer cell lines and 28-day repeated oral toxicity study in Sprague-Dawley rats
BackgroundGinseng ( Panax ginseng C.A. Mey.) has been used as a valuable ingredient in traditional medicine for thousands of years mostly in Asian...
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Cytotoxic effects of Trachyspermum ammi and Ferula assafoetida on MCF-7 and MDA-MB-468 breast cancer cell lines
BackgroundThe induction of oxidative stress is one of the most important cancer etiologies. Plant essential oils contain many effective antioxidant...
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Circulating subpopulations of non-cytotoxic ILCs in diffuse large B-cell lymphoma
Non-cytotoxic innate lymphoid cells (ILCs) have been added to the list of immune cells that may contribute to the tumor microenvironment. Elevated...
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Antimicrobial, antioxidant, and cytotoxic properties of endophytic fungi isolated from Thysanolaena maxima Roxb., Dracaena spicata Roxb. and Aglaonema hookerianum Schott.
BackgroundEndophytic fungi have recently been recognized as an impressive source of natural biomolecules. The primary objective of the research was...
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Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy
Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to...
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The effect of ciprofloxacin on doxorubicin cytotoxic activity in the acquired resistance to doxorubicin in DU145 prostate carcinoma cells
The present study aimed to assess the influence of ciprofloxacin (CIP) against the doxorubicin (DOX)-resistant androgen-independent prostate cancer...
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Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers
BackgroundCancer represents one of the biggest healthcare issues confronting humans and one of the big challenges for scientists in trials to dig...
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Cytotoxic flavone-C-glycosides from the leaves of Dypsis pembana (H.E.Moore) Beentje & J.Dransf., Arecaceae: in vitro and molecular docking studies
BackgroundCancer poses a health threat, with an increased incidence worldwide. Thus, it is essential to develop new natural anticancer agents. Dypsis...
