Search
Search Results
-
Screening antivirals with a mCherry-expressing recombinant bovine respiratory syncytial virus: a proof of concept using cyclopamine
Bovine respiratory syncytial virus (BRSV) is a pathogenic pneumovirus and a major cause of acute respiratory infections in calves. Although different...
-
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
BackgroundHirschsprung disease (HSCR) is a congenital intestinal disease characterised by functional obstruction of the colon. Herein, we...
-
GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway
Polycystic ovary syndrome (PCOS) is a gynaecological endocrine disease. The objective of the present study was to investigate the role of GTPase...
-
Comprehensive analysis and prognostic assessment of senescence-associated genes in bladder cancer
BackgroundThe prevalence and mortality of bladder cancer (BLCA) present a significant medical challenge. While the function of senescence-related...
-
Protective role of SIRT1-mediated Sonic Hedgehog signaling pathway in the preeclampsia rat models
ObjectiveTo explore the role of silent information regulator 1 (SIRT1)-mediated Sonic Hedgehog (SHH) pathway in reduced uterine perfusion pressure...
-
The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury
ObjectiveThis study was designed to observe the expression of important hedgehog (Hh) signal factors in the bone tissue of rats with chronic...
-
Cuproptosis-related signature for clinical prognosis and immunotherapy sensitivity in hepatocellular carcinoma
BackgroundCopper homeostasis imbalance has been implicated in tumor progression, aggressiveness, and treatment response. However, the precise roles...
-
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no...
-
Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application
Sarcomas are a diverse group of malignant neoplasms of mesenchymal origin. They develop rarely, but due to poor prognosis, they are a challenging and...
-
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies
The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling...
-
Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and...
-
Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma
Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM). In TME, several signaling molecules, growth...
-
Aponermin: First Approval
Aponermin (沙艾特) is a recombinant circularly permuted human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) developed by Bei**g...
-
Possible correlation of sonic hedgehog signaling with epithelial–mesenchymal transition in muscle-invasive bladder cancer progression
PurposeTo investigate the role of sonic hedgehog (Shh) signaling and epithelial–mesenchymal transition (EMT) in bladder cancer progression and...
-
Construction and validation of a cuproptosis-related lncRNA prognosis signature in bladder carcinoma
BackgroundBladder cancer (BLCA) is a prevalent urological tumor with high morbidity and mortality. However, BLCA treatment remains challenging due to...
-
On the horizon: Hedgehog signaling to heal broken bones
Uncovering the molecular pathways that drive skeletal repair has been an ongoing challenge. Initial efforts have relied on in vitro assays to...
-
Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies
Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom...
-
Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BackgroundThe hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently...
-
New Emerging Treatment Options for Advanced Basal Cell Carcinoma and Squamous Cell Carcinoma
Non-melanoma skin cancers, also known as keratinocyte tumors, have an increasing incidence worldwide, with basal cell carcinoma and squamous cell...
-
Olfactory Neuroblastoma: Treatment Strategies for Advanced Disease
Purpose of ReviewThis review seeks to synthesize emerging literature and expert management recommendations of olfactory neuroblastoma (ONB), a rare...
