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Investigating Neurocardiac Autonomic Regulation and Cortical Excitability Measures in Patients with Major Depressive Disorder
Major depressive disorders (MDD) are among the most common psychiatric disorders affecting people worldwide. The steady increase in cases of...
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An investigation of the acute effects of aerobic exercise on executive function and cortical excitability in adolescents with attention deficit hyperactivity disorder (ADHD)
Previous studies have shown that aerobic exercise has beneficial effects on executive function in adolescents with attention-deficit hyperactivity...
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Effects of dry needling on spasticity, cortical excitability, and range of motion in a patient with multiple sclerosis: a case report
BackgroundDry needling is an intervention used by physiotherapists to manage muscle spasticity. We report the effects of three sessions of dry...
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Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task
BackgroundMigraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. The latter is manifested...
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Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndrome
BackgroundFibromyalgia syndrome is a widespread chronic pain condition identified by body-wide pain, fatigue, cognitive fogginess, and sleep issues....
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Dynamic brainstem and somatosensory cortical excitability during migraine cycles
Abstract BackgroundMigraine has complex pathophysiological characteristics and episodic attacks. To decipher the cyclic neurophysiological features...
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Visual-stress-related cortical excitability as a prospective marker for symptoms of depression and anxiety in young people
Visual stress is thought to reflect cortical excitability and has been associated with many neurological, neuropsychiatric, and neurodevelopmental...
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Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
BackgroundNeurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus...
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Individualized time windows enhance TMS-EEG signal characterization and improve assessment of cortical function in schizophrenia
Transcranial magnetic stimulation and electroencephalography (TMS-EEG) recordings are crucial to directly assess cortical excitability and inhibition...
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Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced...
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Correlation of bilateral M1 hand area excitability and overall functional recovery after spinal cord injury: protocol for a prospective cohort study
BackgroundAfter spinal cord injury (SCI), a large number of survivors suffer from severe motor dysfunction (MD). Although the injury site is in the...
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Nerve excitability test and lead toxicity: a case-control study
BackgroundAlthough conventional electrophysiological parameters have been proposed as clinical indicators for monitoring lead neuropathies, their...
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Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders
Excitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are...
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Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a randomized controlled trial
BackgroundMultiple sclerosis (MS) is a degenerative disease of the central nervous system (CNS) that disrupts walking function and results in other...
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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium channel...
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Exploratory genome-wide analyses of cortical inhibition, facilitation, and plasticity in late-life depression
Late-life depression (LLD) is a heterogenous mood disorder influenced by genetic factors. Cortical physiological processes such as cortical...
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Anesthesia inhibited corticospinal excitability and attenuated the modulation of repetitive transcranial magnetic stimulation
BackgroundLots of studies have measured motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) in anesthetized animals....
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Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure...
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Early impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer’s disease mouse model
Genetic risk factors for neurodegenerative disorders, such as Alzheimer’s disease (AD), are expressed throughout the life span. How these risk...
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Glucocorticoid-glucocorticoid receptor-HCN1 channels reduce neuronal excitability in dorsal hippocampal CA1 neurons
While chronic stress increases hyperpolarization-activated current ( I h ) in dorsal hippocampal CA1 neurons, the underlying molecular mechanisms are...