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Adjuvant convection-enhanced delivery for the treatment of brain tumors
BackgroundMalignant gliomas are a therapeutic challenge and remain nearly uniformly fatal. While new targeted chemotherapeutic agentsagainst...
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Strategies to Improve Drug Delivery Across the Blood–Brain Barrier for Glioblastoma
Purpose of ReviewGlioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has...
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ISSLS prize in clinical/bioengineering science 2024: How standing and supine positions influence nutrient transport in human lumbar discs?—A serial post-contrast MRI study evaluating interplay between convection and diffusion
PurposeThe intervertebral disc being avascular depends on diffusion and load-based convection for essential nutrient supply and waste removal. There...
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The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However,...
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Blood–Brain Barrier Disruption for the Treatment of Primary Brain Tumors: Advances in the Past Half-Decade
Purpose of ReviewTo review relevant advances in the past half-decade in the treatment of primary brain tumors via modification of blood–brain barrier...
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New Drug Delivery Systems Developed for Brain Targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (B CSF ) are two of the most complex and sophisticated concierges that defend...
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Radiation therapy combined with intracerebral convection-enhanced delivery of cisplatin or carboplatin for treatment of the F98 rat glioma
BackgroundThe purpose of this review is to summarize our own experimental studies carried out over a 13-year period of time using the F98 rat glioma...
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Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review
BackgroundProcess intensification is a major hurdle in pharmaceutical process scale-up. Solvent removal strategies have limited the effectiveness of...
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Advances in local therapy for glioblastoma — taking the fight to the tumour
Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains one of the most treatment-resistant CNS malignancies, and the...
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Fifty years of DIPG: looking at the future with hope
Diffuse intrinsic pontine glioma (DIPG) is a primary brainstem tumor of childhood that carries a dismal prognosis, with median survival of less than...
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Radiation nanomedicines for cancer treatment: a scientific journey and view of the landscape
BackgroundRadiation nanomedicines are nanoparticles labeled with radionuclides that emit α- or β-particles or Auger electrons for cancer treatment....
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Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target...
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Advances in ocular drug delivery systems
AbstractRecent advances in pharmacological agents have led to successful treatment of a variety of retinal diseases such as neovascular age-related...
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Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the clinic represents the culmination of decades of research....
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Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic–ischaemic brain injury after cardiac arrest
The cerebral oxygen cascade includes three key stages: (a) convective oxygen delivery representing the bulk flow of oxygen to the cerebral vascular...
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Continuous renal replacement therapy in neonates and children: what does the pediatrician need to know? An overview from the Critical Care Nephrology Section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)
Continuous renal replacement therapy (CRRT) is the preferred method for renal support in critically ill and hemodynamically unstable children in the...
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The recent insight in the release of anticancer drug loaded into PLGA microspheres
Cancer is a series of diseases leading to a high rate of death worldwide. Microspheres display specific characteristics that make them appropriate...
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Current state of therapeutic focused ultrasound applications in neuro-oncology
IntroductionDespite manifold advances in oncology, cancers of the central nervous system remain among the most lethal. Unique features of the brain,...
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Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors
IntroductionOpening of the blood–brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now...
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Smart nanoparticles for cancer therapy
Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer...
