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Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP)....
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Low levels of complement factor C3 at diagnosis can predict outcome in antineutrophil antibody associated vasculitis
IntroductionExperimental data support the involvement of complement in the pathogenesis of antineutrophil antibody associated vasculitis, and...
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Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome
BackgroundAtypical hemolytic uremic syndrome (aHUS) can be associated with mutations, deletions, or hybrid genes in factor H-related (FHR) proteins.
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An unusual case of adult-onset still’s disease complicated with anti-complement factor H antibodies associated atypical haemolytic uraemic syndrome
BackgroundAtypical haemolytic uremic syndrome (aHUS) is an uncommon form of thrombotic microangiopathy (TMA). However, it remains difficult to...
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Complement factor D is linked to platelet activation in human and rodent sepsis
BackgroundThe complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact...
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete...
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Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer’s disease of different severity
BackgroundAlzheimer’s disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the...
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The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis
BackgroundPatients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Subclinical carotid...
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Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome
BackgroundCoexisting genetic variants in patients with anti-factor H (FH)-associated atypical hemolytic uremic syndrome (aHUS) have implications for...
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Canonical and non-canonical roles of complement in atherosclerosis
Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of...
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Serum fibroblast growth factor-2 levels complement vital biomarkers for diagnosing heart failure
BackgroundEarly diagnosis of atrial fibrillation is important as it is crucial for improving patient outcomes. Fibroblast growth factor-2 (FGF2) may...
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The role of complement in kidney disease
The complement cascade comprises soluble and cell surface proteins and is an important arm of the innate immune system. Once activated, the...
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High level of serum complement 3 is a risk factor for vascular stenosis progression in TA patients receiving tocilizumab: a prospective observational study
BackgroundThe IL-6R antibody tocilizumab has been proven effective in treating Takayasu arteritis (TA). However, some patients show silent vascular...
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Complement System Deficiencies in Elite Athletes
BackgroundAlthough regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in...
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Complosome — the intracellular complement system
The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known...
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Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk
Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains...
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The complement cascade in lung injury and disease
BackgroundThe complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major...
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Complement therapeutics are coming of age in rheumatology
The complement system was described over 100 years ago, and it is well established that activation of this pathway accompanies the great majority of...
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Association of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naïve patients with first-episode schizophrenia
Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been...
