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Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP)....
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Low levels of complement factor C3 at diagnosis can predict outcome in antineutrophil antibody associated vasculitis
IntroductionExperimental data support the involvement of complement in the pathogenesis of antineutrophil antibody associated vasculitis, and...
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Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome
BackgroundAtypical hemolytic uremic syndrome (aHUS) can be associated with mutations, deletions, or hybrid genes in factor H-related (FHR) proteins.
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An unusual case of adult-onset still’s disease complicated with anti-complement factor H antibodies associated atypical haemolytic uraemic syndrome
BackgroundAtypical haemolytic uremic syndrome (aHUS) is an uncommon form of thrombotic microangiopathy (TMA). However, it remains difficult to...
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Serum fibroblast growth factor-2 levels complement vital biomarkers for diagnosing heart failure
BackgroundEarly diagnosis of atrial fibrillation is important as it is crucial for improving patient outcomes. Fibroblast growth factor-2 (FGF2) may...
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Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy
PurposeFew studies have reported the roles of the complement system in concomitant idiopathic membranous nephropathy and IgA nephropathy (IMN-IgAN)....
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete...
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Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer’s disease of different severity
BackgroundAlzheimer’s disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the...
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Association of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naïve patients with first-episode schizophrenia
Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been...
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Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome
BackgroundCoexisting genetic variants in patients with anti-factor H (FH)-associated atypical hemolytic uremic syndrome (aHUS) have implications for...
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Canonical and non-canonical roles of complement in atherosclerosis
Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of...
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The role of complement in kidney disease
The complement cascade comprises soluble and cell surface proteins and is an important arm of the innate immune system. Once activated, the...
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Complement C3 Facilitates Stratification of Stages of Chronic Hepatitis B and Signifies Development of Acute-on-Chronic Liver Failure in Acute Decompensated Cirrhosis
IntroductionPatients with chronic hepatitis B (CHB) have a dynamic disease process and risk of end-stage liver disease. It is critical to...
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High level of serum complement 3 is a risk factor for vascular stenosis progression in TA patients receiving tocilizumab: a prospective observational study
BackgroundThe IL-6R antibody tocilizumab has been proven effective in treating Takayasu arteritis (TA). However, some patients show silent vascular...
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Complosome — the intracellular complement system
The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known...
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Complement System Deficiencies in Elite Athletes
BackgroundAlthough regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in...
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A novel missense mutation in complement factor I predisposes patients to atypical hemolytic uremic syndrome: a case report
BackgroundAtypical hemolytic uremic syndrome, also called the nondiarrheal form of hemolytic uremic syndrome, is a rare disease characterized by the...
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Anti-factor B antibodies in atypical hemolytic uremic syndrome
BackgroundThe etiology of atypical hemolytic uremic syndrome (aHUS) is unknown in 30–40% of patients. Anti-factor B (FB) antibodies are reported in...
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The complement cascade in lung injury and disease
BackgroundThe complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major...
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The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis
BackgroundPatients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Subclinical carotid...