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The role of complement in kidney disease
The complement cascade comprises soluble and cell surface proteins and is an important arm of the innate immune system. Once activated, the...
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Complement inhibitors in pediatric kidney diseases: new therapeutic opportunities
Historically, the complement system (classical, lectin, alternative, and terminal pathways) is known to play a crucial role in the etiopathogenesis...
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The complement cascade in lung injury and disease
BackgroundThe complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major...
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Complement therapeutics are coming of age in rheumatology
The complement system was described over 100 years ago, and it is well established that activation of this pathway accompanies the great majority of...
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Outcome of atypical hemolytic uremic syndrome: role of triggers and complement abnormalities in the response to C5 inhibition
BackgroundAtypical-hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy often due to uncontrolled complement activation,...
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Complement activation and blockade in massive post-partum haemorrhage, thrombotic microangiopathy and acute kidney injury: a case report
BackgroundThrombotic microangiopathy (TMA)-mediated acute kidney injury (AKI) following massive haemorrhage is a rare but severe complication of the...
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Evaluation of the significance of complement-related genes mutations in atypical postinfectious glomerulonephritis: a pilot study
BackgroundPostinfectious glomerulonephritis with C3-dominant glomerular deposition (C3-PIGN) involves C3-dominant glomerular deposition without...
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Low levels of complement factor C3 at diagnosis can predict outcome in antineutrophil antibody associated vasculitis
IntroductionExperimental data support the involvement of complement in the pathogenesis of antineutrophil antibody associated vasculitis, and...
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Atypical HUS and Crohn’s disease—interference of intestinal disease activity with complement-blocking treatment
BackgroundIn atypical hemolytic-uremic syndrome (aHUS), various defects of the complement system have been reported to explain pathophysiology....
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Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease
IgA nephropathy (IgAN) is still one of the leading causes of end-stage kidney disease (ESRD), and complement system activation is a key to the...
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Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization
BackgroundNonalcoholic steatohepatitis (NASH) is an advanced form of chronic fatty liver disease, which is a driver of hepatocellular carcinoma....
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An unusual case of adult-onset still’s disease complicated with anti-complement factor H antibodies associated atypical haemolytic uraemic syndrome
BackgroundAtypical haemolytic uremic syndrome (aHUS) is an uncommon form of thrombotic microangiopathy (TMA). However, it remains difficult to...
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Vitamin D3 improved hypoxia-induced lung injury by inhibiting the complement and coagulation cascade and autophagy pathway
BackgroundPulmonary metabolic dysfunction can cause lung tissue injury. There is still no ideal drug to protect against...
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The Role of Complement in HSCT-TMA: Basic Science to Clinical Practice
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a common complication occurring post-HSCT and is...
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Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities
Myasthenia gravis is an autoimmune disorder defined by muscle weakness and fatigability associated with antibodies against proteins of the...
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Complement Inhibition in Paroxysmal Nocturnal Hemoglobinuria (PNH): A Systematic Review and Expert Opinion from Central Europe on Special Patient Populations
IntroductionHemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is complement-mediated due to the lack of complement inhibitors in the hemopoietic...
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A case of idiopathic nodular glomerulosclerosis successfully treated by intensive blockade of the renin–angiotensin–aldosterone system
Idiopathic nodular glomerulosclerosis has a poor renal prognosis and is characterized by diffuse nodular glomerulosclerotic lesions in the absence of...
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Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome
BackgroundCoexisting genetic variants in patients with anti-factor H (FH)-associated atypical hemolytic uremic syndrome (aHUS) have implications for...
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Anaphylactic Responses to Neuromuscular Blockade Drugs and Reversal Drugs
Purpose of ReviewThis review discusses the incidence of anaphylaxis to neuromuscular blockade drugs (NMBDs), the mechanism and clinical features, as...
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Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice
Collagen expression and structure in the tumour microenvironment are associated with tumour development and therapy response. Leukocyte-associated...
