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Immunostimulatory effects of Nannochloropsis oculata supplementation on Barki rams growth performance, antioxidant assay, and immunological status
BackgroundNatural feed supplements are gaining popularity in the animal production sector due to their safety and potential immunostimulatory...
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HPLC analysis, genotoxic and antioxidant potential of Achillea millefolium L. and Chaerophyllum villosum Wall ex. Dc
BackgroundMethanolic and chloroformic extract of Achillea millefolium and Chaerophyllum villosum were evaluated for HPLC analysis, genotoxic and...
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Olaparib enhances sensitization of BRCA-proficient breast cancer cells to x-rays and protons
PurposeThis study aimed to compare the radiosensitizing effect of the PARP inhibitor, Olaparib, between proton and X-rays irradiations in...
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Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage
In recent years, a number of novel pharmaceutical agents have received approval for the management of acute myeloid leukemia (AML). However, there is...
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Flavokawain C inhibits proliferation and migration of liver cancer cells through FAK/PI3K/AKT signaling pathway
PurposeThis study investigated the potential applicability and the underlying mechanisms of flavokawain C, a natural compound derived from kava...
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Evaluation of DNA damage induced by ionizing radiation from myocardial perfusion imaging: a pilot study
BackgroundAs patient exposure to ionizing radiation raises concern about malignancy risks, this study evaluated the effect of ionizing radiation on...
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Comparison of DNA damage in granulosa cells of women undergoing controlled ovarian stimulation in in vitro fertilization protocols with the recombinant human follicle-stimulating hormones Corneumon®, Gonal-F®, Pergoveris® and Puregon®: a randomized trial
PurposeTo compare the DNA damage in granulosa cells (GCs) of women undergoing ovarian-stimulated cycles with four widely used recombinant human...
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Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer
Synthetic lethality is a novel model for cancer therapy. To understand the function and mechanism of BEN domain-containing protein 4 (BEND4) in...
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Grape Seed Components as Protectors of Inflammation, DNA Damage, and Cancer
Purpose of ReviewOxidative stress is related to the pathogenesis of several chronic diseases, including inflammatory processes. Free radicals excess...
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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
ObjectiveAbnormal expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) was reported to be closely related to the...
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Genotoxic effect of Tamiflu and Adamine on DNA content in male albino mice
BackgroundTamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The...
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PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
BackgroundColorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response....
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SNHG15 enhances cisplatin resistance in lung adenocarcinoma by affecting the DNA repair capacity of cancer cells
BackgroundLung adenocarcinoma (LUAD) is a prevalent malignancy. SNHG15 has been demonstrated to be oncogenic in many kinds of cancers, however the...
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Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells
BackgroundDespite rapid developments in immunotherapy and targeted therapy, dacarbazine (DTIC)-based chemotherapy still has been placed at the...
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Evaluation of the cytotoxic and genotoxic/antigenotoxic effects of resveratrol in human limbal explant cultures
PurposeResveratrol (RSV) is a natural polyphenol phytoalexin compound and has long been considered to possess antioxidant and anti-inflammatory...
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The anticancer effects of thymol on HepG2 cell line
There is an increasing incidence of liver cancer, which is a hazard for global health. The present study was designed to evaluate possible cytotoxic,...
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Overexpression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation
PurposePOU3F2 is associated with malignant behaviors and poor prognosis in cancer. However, the function and mechanism of POU3F2 in breast cancer...
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Association between occupational noise-induced hearing loss and genotoxicity among textile factory workers
Background/aimHearing loss caused by exposure to noise is still among the most prevalent health risks for industrial workers. This study aims to...
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Evaluating the efficacy of Nd:YAG fourth harmonic (266 nm) in comparison with ArF excimer (193 nm) in laser corneal resha**: ex vivo pilot study
PurposeLaser corneal resha** is a common eye surgery utilized to overcome many vision disorders. Different UV laser wavelengths can be effective in...
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miR-4796 enhances the sensitivity of breast cancer cells to ionising radiation by impairing the DNA repair pathway
BackgroundMicroRNAs (miRNAs) are important regulators of DNA damage response (DDR) through post-transcriptional regulation on their target genes,...
