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Changes in type VI collagen degradation reflect clinical response to treatment in rheumatoid arthritis patients treated with tocilizumab
ObjectivesRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in multiple articular joints, causing pain, joint...
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Longitudinal serological assessment of type VI collagen turnover is related to progression in a real-world cohort of idiopathic pulmonary fibrosis
BackgroundRemodeling of the extracellular matrix (ECM) is a central mechanism in the progression of idiopathic pulmonary fibrosis (IPF), and...
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Type IV Collagen Promotes Adipogenic Differentiation of Adipose Stem Cells
Type IV collagen is a major component of the extracellular matrix in adipose tissue. It is secreted during the lipogenic differentiation of...
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Causative variant profile of collagen VI-related dystrophy in Japan
BackgroundCollagen VI-related dystrophy spans a clinical continuum from severe Ullrich congenital muscular dystrophy to milder Bethlem myopathy. This...
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The collagen matrix regulates the survival and function of pancreatic islets
The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of cells, including pancreatic cells. Collagens are the most...
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Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV
Background and aimsLiver-associated complications still frequently lead to mortality in people with HIV (PWH), even though combined antiretroviral...
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Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism?
BackgroundDiabetic cardiovascular autonomic neuropathy (CAN) and distal symmetrical polyneuropathy (DSPN) are severe diabetic complications. Collagen...
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Study of the collagen type VI alpha 3 (COL6A3) gene in Parkinson’s disease
BackgroundTo date, the genetic contribution to Parkinson’s disease (PD) remains unclear. Mutations in the collagen type VI alpha 3 ( COL6A3 ) gene...
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Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis
BackgroundAberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We...
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Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia
BackgroundPlatelet glycoprotein VI (GPVI) receptor is essential for platelet adhesion and aggregation. Eltrombopag is as an effective treatment for...
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Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications
Collagen is an essential constituent of the uterine extracellular matrix that provides biomechanical strength, resilience, structural integrity, and...
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Visualizing Collagen Fibrils in the Cochlea’s Tectorial and Basilar Membranes Using a Fluorescently Labeled Collagen-Binding Protein Fragment
PurposeA probe that binds to unfixed collagen fibrils was used to image the shapes and fibrous properties of the TM and BM. The probe (CNA35) is...
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Aging impairs the osteocytic regulation of collagen integrity and bone quality
Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality,...
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Nano-calcium incorporated piscean collagen scaffolds: potential wound dressing material
BackgroundCollagen proteins extracted from piscean sources are alternatives to bovine and porcine collagen because of their abundance, low price, and...
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Unraveling the genetic collagen connection: clinical and therapeutic insights on genetic connective tissue disorders
Hereditary connective tissue disorders include more than 200 conditions affecting different organs and tissues, compromising the biological role of...
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Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth
Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (~50%) survive <1 year,...
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Beneficial Effects of Multi-Micronutrient Supplementation with Collagen Peptides on Global Wrinkles, Skin Elasticity and Appearance in Healthy Female Subjects
IntroductionWith ageing, collagen production slows down, leading to wrinkle appearance and loss of elasticity. Replenishing key structural molecules...
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Collagen Type IV Alpha 5 Chain in Bronchiolitis Obliterans Syndrome After Lung Transplant: The First Evidence
IntroductionBronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive...
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A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype
BackgroundAsthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly...
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Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced...
