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Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations
Disrupted sleep is a symptom of many psychiatric disorders, including substance use disorders. Most drugs of abuse, including opioids, disrupt sleep....
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Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats
Chronic morphine administration alters gene expression in different brain regions, an effect which may contribute to plastic changes associated with...
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Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA neurotransmission in D2-MSNs of the accumbens-pallidal pathway in male mice
Relapse is a major challenge in the treatment of drug addiction, and exercise has been shown to decrease relapse to drug seeking in animal models....
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Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse....
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RETRACTED ARTICLE: Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapies
BackgroundChronic morphine usage induces lasting molecular and microcellular adaptations in distinct brain areas, resulting in addiction-related...
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Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA)
BackgroundIn emergency medicine, pain is a frequent reason for consultation. However, there is a great variation in its management which is often...
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Comparison of intrathecal morphine and low-dose bupivacaine with intravenous morphine for postoperative analgesia in laparoscopic liver resection: a randomized controlled trial
BackgroundLaparoscopic liver surgery has undergone substantial advancements over the past few decades, and the key to this improvement has been an...
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Omission of perioperative morphine reduces postoperative pain in proctological interventions: a single-center analysis
There is an increase in outpatient procedures and this trend will continue in the future. For hemorrhoidectomy, it is the standard of treatment in...
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Different projection neurons of basolateral amygdala participate in the retrieval of morphine withdrawal memory with diverse molecular pathways
Context-induced retrieval of drug withdrawal memory is one of the important reasons for drug relapses. Previous studies have shown that different...
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Efficacy and Adverse Effects of IV Morphine for Burn Pain Management in the Emergency Department: An Observational Study
IntroductionThe management of pain following a burn is extremely complex because of the multifactorial nature of burn pain (nociceptive and...
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Effectiveness and safety of prehospital analgesia with nalbuphine and paracetamol versus morphine by paramedics - an observational study
BackgroundDespite the development of various analgesic concepts, prehospital oligoanalgesia remains very common. The present work examines...
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Influence of a chronic beta-blocker therapy on perioperative opioid consumption – a post hoc secondary analysis
BackgroundBeta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with...
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Patient-controlled analgesia morphine for the management of acute pain in the emergency department: a systematic review and meta-analysis
BackgroundThe ideal pain control approach is typically viewed as titration of analgesia for pain reduction and periodic pain evaluation. However,...
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Natural history of pediatric morphine leukoencephalopathy on CT and MRI
An increased awareness of opioids and the imaging appearance in opioid overdose–related leukoencephalopathy has rapidly become crucial with respect...
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Current Review of the Use of Intrathecal Morphine for Postoperative Analgesia in Total Joint Arthroplasty
Purpose of ReviewThe use of neuraxial opioids (NAO) as a method for postoperative analgesia for patients undergoing total joint arthroplasty (TJA) is...
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The 50% effective dose of hydromorphone and morphine for epidural analgesia in the hemorrhoidectomy: a double-blind, sequential dose-finding study
BackgroundAlthough previous studies have showed that epidural morphine can be used as a complement to local anesthetics for analgesia after...
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Negative Impact of ST-Segment Elevation Myocardial Infarction and Morphine Dose on Ticagrelor Uptake and Pharmacodynamics: A Population PK/PD Analysis of Pooled Individual Participant Data
BackgroundTicagrelor is widely used in patients with stable and acute coronary artery disease. Understanding the factors that influence its...
