Search
Search Results
-
Structure-based mechanism and inhibition of cholesteryl ester transfer protein
Purpose of ReviewCholesteryl ester transfer proteins (CETP) regulate plasma cholesterol levels by transferring cholesteryl esters (CEs) among...
-
CETP Inhibitors: Should We Continue to Pursue This Pathway?
Purpose of ReviewFor more than 20 years there has been considerable interest in the development of pharmacological inhibitors of cholesteryl ester...
-
Pharmacokinetics, Safety and Tolerability of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein (CETP) Inhibitor, After Single and Multiple Doses in Healthy Chinese Subjects
IntroductionAnacetrapib is a novel, powerful cholesteryl ester transfer protein (CETP) inhibitor with bidirectional lipid regulation, which was...
-
ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer
BackgroundBiliary tract cancer (BTC) has few choices of chemotherapy, including gemcitabine, therefore exploring the mechanisms of gemcitabine...
-
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
Purpose of ReviewTo discuss the history of cardiovascular outcomes trials of cholesteryl ester transfer protein (CETP) inhibitors and to describe...
-
Alterations of lipid metabolism, blood pressure and fatty liver in spontaneously hypertensive rats transgenic for human cholesteryl ester transfer protein
Cholesteryl ester transfer protein (CETP) mediates a step in reverse cholesterol transport, which channels cholesterol from peripheral tissues back...
-
Do Cholesteryl Ester Transfer Protein Inhibitors Have a Role in the Treatment of Cardiovascular Disease?
Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism and has presented an attractive target for drug development,...
-
Novel and future lipid-modulating therapies for the prevention of cardiovascular disease
Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Several...
-
Role of apolipoprotein C1 in lipoprotein metabolism, atherosclerosis and diabetes: a systematic review
Apolipoprotein C1 (apoC1) is a small size apolipoprotein whose exact role is not totally clarified but which seems to modulate significantly the...
-
Blood Biomarkers of Alcohol Use: A Sco** Review
Purpose of ReviewUnderstanding whether a person has consumed alcohol or not, as well as quantitative assessment of alcohol use, are often based on...
-
Emerging Pharmacotherapy to Reduce Elevated Lipoprotein(a) Plasma Levels
Lipoprotein(a) is a unique form of low-density lipoprotein. It is associated with a high incidence of premature atherosclerotic disease such as...
-
HDL and type 2 diabetes: the chicken or the egg?
HDL is a complex macromolecular cluster of various components, such as apolipoproteins, enzymes and lipids. Quality evidence from clinical and...
-
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
-
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD),...
-
Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development
Drug development in cardiovascular disease is stagnating, with lack of efficacy and adverse effects being barriers to innovation. Human genetics can...
-
High-density lipoproteins, reverse cholesterol transport and atherogenesis
Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic cardiovascular disease (ASCVD). According to a widely...
-
Comparative Analysis of Atherogenic Lipoproteins L5 and Lp(a) in Atherosclerotic Cardiovascular Disease
Purpose of ReviewLow-density lipoprotein (LDL) poses a risk for atherosclerotic cardiovascular disease (ASCVD). As LDL comprises various subtypes...
-
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting...
-
Proteomics of high-density lipoprotein subfractions and subclinical atherosclerosis in type 1 diabetes mellitus: a case–control study
BackgroundSubclinical atherosclerosis is frequently observed in type 1 diabetes (T1D) although the mechanisms and markers involved in the evolution...
-
Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy...
